| PID00003 |
|
Capsaicin |
3000 nM |
- |
Homo sapiens |
Cytochrome P450 1A2 |
CHEMBL1909046 |
DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) |
| PID00003 |
|
Capsaicin |
3800 nM |
- |
Homo sapiens |
Cyclooxygenase-1 |
J. Nat. Prod., (2005) 68:7:985 |
Inhibition of COX1 |
| PID00003 |
|
Capsaicin |
52480.75 nM |
- |
Bos taurus |
NADH-ubiquinone oxidoreductase chain 1 |
Biochim. Biophys. Acta, (1996) 1273:1:21 |
Inhibition of Bos taurus (bovine) heart submitochondrial particle NDH1 assessed as NADH-DB reductase activity |
| PID00003 |
|
Capsaicin |
28000 nM |
- |
Mus musculus |
Transient receptor potential cation channel subfamily M member 8 |
J. Nat. Prod., (2014) 77:2:285 |
Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of menthol-induced intracellular Ca2+ influx by fluorescence-based assay |
| PID00003 |
|
Capsaicin |
19 nM |
- |
Rattus norvegicus |
Vanilloid receptor |
Bioorg. Med. Chem. Lett., (2010) 20:23:7137 |
Binding affinity to rat TRPV1 |
| PID00003 |
|
Capsaicin |
8 nM |
- |
Homo sapiens |
Vanilloid receptor |
Bioorg. Med. Chem. Lett., (2015) 25:5:1009 |
Antagonist activity against human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx pre-treated 5 mins before capsaicin addition by Fluo-4 dye based assay |
| PID00003 |
|
Capsaicin |
- |
- |
Homo sapiens |
Vascular endothelial growth factor receptor 1 |
CHEMBL1909046 |
DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) |
| PID00003 |
|
Capsaicin |
- |
- |
Homo sapiens |
Vasoactive intestinal polypeptide receptor 1 |
CHEMBL1909046 |
DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) |
| PID00003 |
|
Capsaicin |
- |
- |
Homo sapiens |
Vasopressin V1a receptor |
CHEMBL1909046 |
DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) |
| PID00003 |
|
Capsaicin |
> 100000 nM |
- |
Mus musculus |
Transient receptor potential cation channel subfamily M member 8 |
J. Nat. Prod., (2014) 77:2:285 |
Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellular Ca2+ influx by fluorescence-based assay |