Assay of Pungent Compounds

PID	Structure	Name	IC50	EC50	Assay Organism	Target Name	Assay_References	Note
PID00005		Butyl Isothiocyanate	-	26.15 ug.mL-1	Pectobacterium carotovorum	Pectobacterium carotovorum	CHEMBL3044893	Antibacterial activity against Pectobacterium carotovorum after 12 hr by turbidometric analysis
PID00005		Butyl Isothiocyanate	-	42.83 ug.mL-1	Rhizoctonia solani	Rhizoctonia solani	CHEMBL3044893	Antifungal activity against Rhizoctonia solani after 24 to 28 min by growth rate method
PID00005		Butyl Isothiocyanate	-	87300 nM	Sclerotinia sclerotiorum	Sclerotinia sclerotiorum	Pest Manag Sci, (2011) 67:7:869	Fungistatic activity in Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in volatile phase measured at 20 degC after 5 days
PID00005		Butyl Isothiocyanate	-	403000 nM	Sclerotinia sclerotiorum	Sclerotinia sclerotiorum	Pest Manag Sci, (2011) 67:7:869	Fungistatic activity in Sclerotinia sclerotiorum assessed as sclerotial viability measured at 20 degC after 5 days
PID00005		Butyl Isothiocyanate	-	932000 nM	Sclerotinia sclerotiorum	Sclerotinia sclerotiorum	Pest Manag Sci, (2011) 67:7:869	Fungistatic activity in Sclerotinia sclerotiorum assessed as inhibition of mycelial growth in contact phase measured at 20 degC after 5 days
PID00026		γ-Terpinene	-	22000 ug.mL-1	-	Radical scavenging activity	J. Nat. Prod., (1995) 58:11:1749	Antioxidant activity assessed as DPPH radical scavenging activity
PID00042		Ethylcinnamate	95 ug.mL-1	-	Homo sapiens	HUVEC	Eur. J. Med. Chem., (2011) 46:11:5498	Antiinflammatory activity against TNF-alpha-induced ICAM1 protein expression in HUVEC pretreated for 2 hrs before TNFalpha challenge measured after 16 hrs by whole cell ELISA
PID00042		Ethylcinnamate	31590 nM	-	Homo sapiens	A-375	Bioorg. Med. Chem. Lett., (2009) 19:21:6078	Cytotoxicity against human A375 cells by MTT assay
PID00042		Ethylcinnamate	35690 nM	-	Homo sapiens	HL-60	Bioorg. Med. Chem. Lett., (2009) 19:21:6078	Cytotoxicity against human HL60 cells by MTT assay
PID00042		Ethylcinnamate	41230 nM	-	Homo sapiens	THP-1	Bioorg. Med. Chem. Lett., (2009) 19:21:6078	Cytotoxicity against human THP1 cells by MTT assay