| PID00003 |
|
Capsaicin |
- |
0.42±0.03 μM |
wild-type |
Transient receptor potential cation channel subfamily V member 1 |
Prescott E D, Julius D. A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity[J]. Science, 2003, 300(5623): 1284-1288. |
- |
| PID00003 |
|
Capsaicin |
17.45 μM |
- |
Homo sapiens |
hERG |
Xing, J., Ma, J., Zhang, P., Fan, X. Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652[J]. European journal of pharmacology, 2010, 630(1-3): 1-9. |
- |
| PID00003 |
|
Capsaicin |
4.11 μM |
- |
Homo sapiens |
hERG |
Xing, J., Ma, J., Zhang, P., Fan, X. Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652[J]. European journal of pharmacology, 2010, 630(1-3): 1-9. |
mutating the Y652 residue to Ala enhances the blockade effect of capsaicin |
| PID00005 |
|
Butyl Isothiocyanate |
231400 nM |
- |
Homo sapiens |
LoVo |
Bioorg. Med. Chem. Lett., (2011) 21:15:4572 |
Antiproliferative activity against doxorubicin-resistant human LoVo cells after 72 hrs by SRB assay |
| PID00005 |
|
Butyl Isothiocyanate |
265000 nM |
- |
Homo sapiens |
Placeholder for assays where the target is a tissue/organism etc |
Bioorg. Med. Chem. Lett., (2016) 26:2:667 |
Antiproliferative activity against human LoVo/DX cells assessed as reduction in cell viability after 72 hrs by SRB assay |
| PID00005 |
|
Butyl Isothiocyanate |
296000 nM |
- |
Homo sapiens |
LoVo |
Bioorg. Med. Chem. Lett., (2016) 26:2:667 |
Antiproliferative activity against human LoVo cells assessed as reduction in cell viability after 72 hrs by SRB assay |
| PID00005 |
|
Butyl Isothiocyanate |
305800 nM |
- |
Homo sapiens |
T47D |
Bioorg. Med. Chem. Lett., (2011) 21:15:4572 |
Antiproliferative activity against human T47D cells after 72 hrs by SRB assay |
| PID00005 |
|
Butyl Isothiocyanate |
324200 nM |
- |
Homo sapiens |
LoVo |
Bioorg. Med. Chem. Lett., (2011) 21:15:4572 |
Antiproliferative activity against human LoVo cells after 72 hrs by SRB assay |
| PID00005 |
|
Butyl Isothiocyanate |
389800 nM |
- |
Homo sapiens |
MCF7 |
Bioorg. Med. Chem. Lett., (2011) 21:15:4572 |
Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay |
| PID00005 |
|
Butyl Isothiocyanate |
413800 nM |
- |
Homo sapiens |
A549 |
Bioorg. Med. Chem. Lett., (2011) 21:15:4572 |
Antiproliferative activity against human A549 cells after 72 hrs by SRB assay |