Assay of Pungent Compounds

PID Structure Name IC50 EC50 Assay Organism Target Name Assay_References Note
PID00014 Myrcene 20.19±0.54 μM - A. lineolatus. AlinCSP5 Sun, L., Zhou, J. J., Gu, S. H., Xiao, H. J., Guo, Y. Y., Liu, Z. W., Zhang, Y. J. Chemosensillum immunolocalization and ligand specificity of chemosensory proteins in the alfalfa plant bug Adelphocoris lineolatus (Goeze)[J]. Scientific reports, 2015, 5: 8073. -
PID00036 Nerolidol 2.00±0.17 μM - A. lineolatus. AlinCSP4 Sun, L., Zhou, J. J., Gu, S. H., Xiao, H. J., Guo, Y. Y., Liu, Z. W., Zhang, Y. J. Chemosensillum immunolocalization and ligand specificity of chemosensory proteins in the alfalfa plant bug Adelphocoris lineolatus (Goeze)[J]. Scientific reports, 2015, 5: 8073. -
PID00036 Nerolidol 23.97±0.97 μM - A. lineolatus. AlinCSP5 Sun, L., Zhou, J. J., Gu, S. H., Xiao, H. J., Guo, Y. Y., Liu, Z. W., Zhang, Y. J. Chemosensillum immunolocalization and ligand specificity of chemosensory proteins in the alfalfa plant bug Adelphocoris lineolatus (Goeze)[J]. Scientific reports, 2015, 5: 8073. -
PID00072 β-Caryophyllene 2.26±0.26 μM - A. lineolatus. AlinCSP4 Sun, L., Zhou, J. J., Gu, S. H., Xiao, H. J., Guo, Y. Y., Liu, Z. W., Zhang, Y. J. Chemosensillum immunolocalization and ligand specificity of chemosensory proteins in the alfalfa plant bug Adelphocoris lineolatus (Goeze)[J]. Scientific reports, 2015, 5: 8073. -
PID00072 β-Caryophyllene 23.97±0.97 μM - A. lineolatus. AlinCSP5 Sun, L., Zhou, J. J., Gu, S. H., Xiao, H. J., Guo, Y. Y., Liu, Z. W., Zhang, Y. J. Chemosensillum immunolocalization and ligand specificity of chemosensory proteins in the alfalfa plant bug Adelphocoris lineolatus (Goeze)[J]. Scientific reports, 2015, 5: 8073. -
PID00139 2-Pentenal, (Z)- - 5 μM Homo sapiens Transient receptor potential cation channel subfamily A member 1 Macpherson, L. J., Dubin, A. E., Evans, M. J., Marr, F., Schultz, P. G., Cravatt, B. F., Patapoutian, A. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines[J]. Nature, 2007, 445(7127): 541. -
PID00006 p-Cresol 4900 nM - Homo sapiens Acetylcholinesterase J. Med. Chem., (1992) 35:3:584 -
PID00003 Capsaicin - 40 nM Homo sapiens Vanilloid receptor Bioorg. Med. Chem. Lett., (2010) 20:1:97 Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level
PID00003 Capsaicin - / Rattus norvegicus Transient receptor potential cation channel subfamily A member 1 Bioorg. Med. Chem. Lett., (2015) 25:5:1009 Agonist activity at rat recombinant TRPA1 expressed in HEK293 cells assessed as Ca2+ influx by Fluo-4 dye based assay
PID00003 Capsaicin - 300 nM Rattus norvegicus Vanilloid receptor J. Med. Chem., (1993) 36:16:2381 In vitro effective concentration for [Ca2+] uptake into dorsal root ganglia neurones in culture