Assay of Pungent Compounds

PID Structure Name IC50 EC50 Assay Organism Target Name Assay_References Note
PID00110 Gingerol 4.62 µM - Homo sapiens PGE2 Dugasani, Swarnalatha, et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol,[8]-gingerol,[10]-gingerol and [6]-shogaol. Journal of ethnopharmacology 127.2 (2010): 515-520. hydroxyl radical
PID00002 1,8-Cineole - 1603 µg/ml Meloidogyne incognita Meloidogyne incognita J Agric Food Chem, (2010) 58:13:7856 -
PID00002 1,8-Cineole - - Homo sapiens MAP kinase ERK2 CHEMBL1909046 -
PID00002 1,8-Cineole 0.06±0.01 mg/ml - Homo sapiens AChE Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil -
PID00004 Piperine 950 nM - Homo sapiens HeLa CHEMBL3045305 -
PID00004 Piperine 42300 nM - Homo sapiens Cathepsin D, CHEMBL3045990 -
PID00004 Piperine - 3162.28 nM Homo sapiens Vanilloid receptor Bioorg. Med. Chem., (2010) 18:9:3299 -
PID00004 Piperine 483 nM - Homo sapiens MAO-B Al-Baghdadi O B, Prater N I, Van der Schyf C J, et al. Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson’s disease[J]. Bioorganic & medicinal chemistry letters, 2012, 22(23): 7183-7188. -
PID00004 Piperine 58.98 µM - Homo sapiens MAO-A Al-Baghdadi O B, Prater N I, Van der Schyf C J, et al. Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson’s disease[J]. Bioorganic & medicinal chemistry letters, 2012, 22(23): 7183-7188. -
PID00007 Eugenol - 20.81 µg/ml Leishmania infantum Leishmania infantum Bioorg. Med. Chem., (2014) 22:21:6250 -