Assay of Pungent Compounds

PID Structure Name IC50 EC50 Assay Organism Target Name Assay_References Note
PID00110 Gingerol 125000 nM - Homo sapiens Cyclooxygenase-2 Bioorg. Med. Chem., (2008) 16:24:10332 -
PID00110 Gingerol - - Homo sapiens Transient receptor potential cation channel subfamily V member 1 Bioorg Med Chem Lett 22: 1674-7 (2012) 10400
PID00110 Gingerol 5000 nM - Homo sapiens VEGF Kim E C, Min J K, Kim T Y, et al. [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo[J]. Biochemical and biophysical research communications, 2005, 335(2): 300-308. -
PID00110 Gingerol 18300 nM - Homo sapiens TRPC5 - -
PID00110 Gingerol 160 µM - Homo sapiens PC-3 Mukkavilli, Rao, et al. Pharmacokinetic-pharmacodynamic correlations in the development of ginger extract as an anticancer agent.Scientific reports 8.1 (2018): 3056. -
PID00110 Gingerol 196 µM - Homo sapiens DU145 Mukkavilli, Rao, et al. "Pharmacokinetic-pharmacodynamic correlations in the development of ginger extract as an anticancer agent." Scientific reports 8.1 (2018): 3056. -
PID00110 Gingerol 12.1 µM - Homo sapiens - Li, Mian, et al. Pungent ginger components modulates human cytochrome P450 enzymes in vitro. Acta Pharmacologica Sinica 34.9 (2013): 1237. -
PID00110 Gingerol 30.7 µM - Homo sapiens CYP2C19 Li, Mian, et al. Pungent ginger components modulates human cytochrome P450 enzymes in vitro. Acta Pharmacologica Sinica 34.9 (2013): 1237. -
PID00110 Gingerol 26.3 µM - Homo sapiens PGE2 Dugasani, Swarnalatha, et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol,[8]-gingerol,[10]-gingerol and [6]-shogaol.Journal of ethnopharmacology 127.2 (2010): 515-520. DPPH radical
PID00110 Gingerol 4.05 µM - Homo sapiens PGE2 Dugasani, Swarnalatha, et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol,[8]-gingerol,[10]-gingerol and [6]-shogaol. Journal of ethnopharmacology 127.2 (2010): 515-520. superoxide radical