Assay of Pungent Compounds

PID Structure Name IC50 EC50 Assay Organism Target Name Assay_References Note
PID00007 Eugenol 236.59 µg/ml - Candida albicans Candida albicans Eur. J. Med. Chem., (2015) 93:null:246 -
PID00007 Eugenol - 261.5 µM Homo sapiens TRPA1 Chung G, Im S T, Kim Y H, et al. Activation of transient receptor potential ankyrin 1 by eugenol[J]. Neuroscience, 2014, 261: 153-160. -
PID00007 Eugenol - 51 µM Mouse mOR-EG-expressing isolated OSNs Oka Y, Katada S, Omura M, et al. Odorant receptor map in the mouse olfactory bulb: in vivo sensitivity and specificity of receptor-defined glomeruli[J]. Neuron, 2006, 52(5): 857-869. -
PID00007 Eugenol - 46 µM Mouse mOR-EG HEK293 cells Oka Y, Katada S, Omura M, et al. Odorant receptor map in the mouse olfactory bulb: in vivo sensitivity and specificity of receptor-defined glomeruli[J]. Neuron, 2006, 52(5): 857-869. -
PID00008 Carvacrol - 7000 nM Homo sapiens Transient receptor potential cation channel subfamily A member 1 J. Med. Chem., (2010) 53:14:5085 -
PID00008 Carvacrol 98000 nM - Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit CHEMBL3638030 -
PID00008 Carvacrol 4000 nM - Homo sapiens Cyclooxygenase-1 J. Nat. Prod., (2005) 68:7:985 -
PID00008 Carvacrol - 404.5 μM Homo sapiens TRPA1 Hasan R, Leeson-Payne A T S, Jaggar J H, et al. Calmodulin is responsible for Ca 2+-dependent regulation of TRPA1 Channels[J]. Scientific reports, 2017, 7: 45098. -
PID00008 Carvacrol 307 μmol/L - Homo sapiens TRPM7 Bae C Y J, Sun H. Current understanding of TRPM7 pharmacology and drug development for stroke[J]. Acta Pharmacologica Sinica, 2013, 34(1): 10. -
PID00010 Thymol 169100 nM 52200 nM Rattus norvegicus Transient receptor potential cation channel subfamily M member 8 Bioorg. Med. Chem. Lett., (2012) 22:10:3535 -