| Name | Length | Bottleneck | Hydropathy | Charge | Polarity | Mutability |
|---|
| Ion channel |
| Name | Description |
|---|
| There are no data to be displayed... | |
| Gene | TRPV1 | |
| PDB ID | 3SUI | |
| Protein Name | ||
| Crystal structure of ca2+-calmodulin in complex with a trpv1 c-terminal peptide(Human & RAT) | ||
| Organism | ||
| Homo sapiens, Rattus norvegicus | ||
| Receptor Name | Transient receptor potential cation channel subfamily V member 1 | |
| UniProt ID | Q8NER1 O35433 | |
| Function | ||
| Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca2+-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis | ||
| Activity regulation | ||
| Channel activity is activated via the interaction with PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity (By similarity). The channel is sensitized by ATP binding. Repeated stimulation with capsaicin gives rise to progressively smaller responses, due to desensitization. This desensitization is triggered by the influx of calcium ions and is inhibited by elevated ATP levels. Ca2+ and CALM displace ATP from its binding site and trigger a conformation change that leads to a closed, desensitized channel. Intracellular PIP2 inhibits desensitization. The double-knot toxin (DkTx) from the Chinese earth tiger tarantula activates the channel and traps it in an open conformation (By similarity). The Scolopendra mutilans RhTx toxin potentiates the heat activation pathway mediated by this channel by binding to the charge-rich outer pore region (in an activated state) (By similarity). | ||
| PID | Structure | Name | Source pungent TCM | FEMA or pubchemCID | Reference |
|---|---|---|---|---|---|
| PID00007 | Eugenol | Ding Xiang | 2467 | - | |
| PID00053 | Linoleic Acid | Ding Xiang | 3380 | - | |
| PID00040 | Geraniol | Gan Jiang | 2507 | - | |
| PID00029 | Nerylacetate | Gan Jiang | 2773 | - | |
| PID00058 | Zingerone | Gan Jiang | 3124 | - | |
| PID00110 | Gingerol | Gan Jiang | pubchem_3473 | - | |
| PID00110 | Gingerol | Pao Jiang | pubchem_3473 | - | |
| PID00058 | Zingerone | Pao Jiang | 3124 | - | |
| PID00040 | Geraniol | Da Suan | 2507 | - | |
| PID00053 | Linoleic Acid | Chuan Xiong | 3380 | - | |
| PID00007 | Eugenol | Guang Huo Xiang | 2467 | - | |
| PID00053 | Linoleic Acid | Wu Yao | 3380 | - | |
| PID00040 | Geraniol | Ba Ji Tian | 2507 | - | |
| PID00040 | Geraniol | Sheng Jiang | 2507 | - | |
| PID00058 | Zingerone | Sheng Jiang | 3124 | - | |
| PID00029 | Nerylacetate | Sheng Jiang | 2773 | - | |
| PID00007 | Eugenol | Sheng Jiang | 2467 | - | |
| PID00032 | Nerol | Sheng Jiang | 2770 | - | |
| PID00110 | Gingerol | Sheng Jiang | pubchem_3473 | - | |
| PID00007 | Eugenol | Bai Zhi | 2467 | - | |
| PID00007 | Eugenol | Mu Ding Xiang | 2467 | - | |
| PID00040 | Geraniol | Di Feng Pi | 2507 | - | |
| PID00007 | Eugenol | Rou Dou Kou | 2467 | - | |
| PID00029 | Nerylacetate | Rou Gui | 2773 | - | |
| PID00007 | Eugenol | Rou Gui | 2467 | - | |
| PID00029 | Nerylacetate | Fang Feng | 2773 | - | |
| PID00007 | Eugenol | Hong Dou Kou | 2467 | - | |
| PID00040 | Geraniol | Hua Jiao | 2507 | - | |
| PID00029 | Nerylacetate | Hua Jiao | 2773 | - | |
| PID00007 | Eugenol | Hua Jiao | 2467 | - | |
| PID00107 | Geranyl Acetate | Hua Jiao | 2509 | - | |
| PID00001 | Allyl Isothiocyanate | Jie Zi | pubchem_5971 | - | |
| PID00112 | Isopropyl Isothiocyanate | Jie Zi | 75263 | - | |
| PID00029 | Nerylacetate | Dou Kou | 2773 | - | |
| PID00007 | Eugenol | Dou Kou | 2467 | - | |
| PID00007 | Eugenol | Xin Yi | 2467 | - | |
| PID00040 | Geraniol | Xin Yi | 2507 | - | |
| PID00029 | Nerylacetate | Xin Yi | 2773 | - | |
| PID00032 | Nerol | Xin Yi | 2770 | - | |
| PID00007 | Eugenol | Pei Lan | 2467 | - | |
| PID00040 | Geraniol | Pei Lan | 2507 | - | |
| PID00032 | Nerol | Pei Lan | 2770 | - | |
| PID00029 | Nerylacetate | Xi Xin | 2773 | - | |
| PID00007 | Eugenol | Xi Xin | 2467 | - | |
| PID00032 | Nerol | Xi Xin | 2770 | - | |
| PID00126 | Menthone | Jing Jie | 2667 | - | |
| PID00004 | Piperine | Bi Ba | 2909 | - | |
| PID00053 | Linoleic Acid | Bi Cheng Qie | 3380 | - | |
| PID00126 | Menthone | Cao Dou Kou | 2667 | - | |
| PID00040 | Geraniol | Cao Guo | 2507 | - | |
| PID00029 | Nerylacetate | Cao Guo | 2773 | - | |
| PID00004 | Piperine | Hu Jiao | 2909 | - | |
| PID00053 | Linoleic Acid | Wei Ling Xian | 3380 | - | |
| PID00040 | Geraniol | Sha Ren | 2507 | - | |
| PID00029 | Nerylacetate | Sha Ren | 2773 | - | |
| PID00007 | Eugenol | Sha Ren | 2467 | - | |
| PID00032 | Nerol | Sha Ren | 2770 | - | |
| PID00029 | Nerylacetate | Xiang Ru | 2773 | - | |
| PID00007 | Eugenol | Xiang Ru | 2467 | - | |
| PID00126 | Menthone | Xiang Ru | 2667 | - | |
| PID00053 | Linoleic Acid | Lai Fu Zi | 3380 | - | |
| PID00007 | Eugenol | Gui Zhi | 2467 | - | |
| PID00040 | Geraniol | Gui Zhi | 2507 | - | |
| PID00029 | Nerylacetate | Gui Zhi | 2773 | - | |
| PID00058 | Zingerone | Gao Liang Jiang | 3124 | - | |
| PID00007 | Eugenol | Gao Liang Jiang | 2467 | - | |
| PID00032 | Nerol | Gao Liang Jiang | 2770 | - | |
| PID00007 | Eugenol | Zi Su Zi | 2467 | - | |
| PID00126 | Menthone | Zi Su Ye | 2667 | - | |
| PID00007 | Eugenol | E Bu Shi Cao | 2467 | - | |
| PID00032 | Nerol | E Bu Shi Cao | 2770 | - | |
| PID00126 | Menthone | Bo He | 2667 | - | |
| PID00040 | Geraniol | Gao Ben | 2507 | - | |
| PID00053 | Linoleic Acid | Sheng Ma | 3380 | - | |
| PID00007 | Eugenol | Sheng Ma | 2467 | - | |
| PID00032 | Nerol | Sheng Ma | 2770 | - | |
| PID00040 | Geraniol | Du Zhong Ye | 2507 | - | |
| PID00007 | Eugenol | Jiu Li Xiang | 2467 | - | |
| PID00040 | Geraniol | Jiu Li Xiang | 2507 | - | |
| PID00053 | Linoleic Acid | Mu Xiang | 3380 | - | |
| PID00053 | Linoleic Acid | Chen Xiang | 3380 | - | |
| PID00029 | Nerylacetate | Ru Xiang | 2773 | - | |
| PID00040 | Geraniol | Xiang Yuan | 2507 | - | |
| PID00029 | Nerylacetate | Xiang Yuan | 2773 | - | |
| PID00053 | Linoleic Acid | Xie Bai | 3380 | - | |
| PID00053 | Linoleic Acid | Ba Dou | 3380 | - | |
| PID00053 | Linoleic Acid | Ban Xia | 3380 | - | |
| PID00110 | Gingerol | Ban Xia | pubchem_3473 | - | |
| PID00029 | Nerylacetate | Ai Ye | 2773 | - | |
| PID00053 | Linoleic Acid | Cang Er Zi | 3380 | - | |
| PID00032 | Nerol | Cang Er Zi | 2770 | - | |
| PID00040 | Geraniol | Chai Hu | 2507 | - | |
| PID00029 | Nerylacetate | Chai Hu | 2773 | - | |
| PID00007 | Eugenol | Chai Hu | 2467 | - | |
| PID00029 | Nerylacetate | Hou Pu | 2773 | - | |
| PID00007 | Eugenol | Hou Pu | 2467 | - | |
| PID00032 | Nerol | Hou Pu | 2770 | - | |
| PID00040 | Geraniol | Hua Ju Hong | 2507 | - | |
| PID00007 | Eugenol | Hua Ju Hong | 2467 | - | |
| PID00040 | Geraniol | Ju Hong | 2507 | - | |
| PID00029 | Nerylacetate | Nan He Shi | 2773 | - | |
| PID00040 | Geraniol | Qian Nian Jian | 2507 | - | |
| PID00032 | Nerol | Qian Nian Jian | 2770 | - | |
| PID00029 | Nerylacetate | She Chuan Zi | 2773 | - | |
| PID00007 | Eugenol | Wu Zhu Yu | 2467 | - | |
| PID00007 | Eugenol | Yin Chen | 2467 | - | |
| PID00007 | Eugenol | Ze Lan | 2467 | - |