| Name | Length | Bottleneck | Hydropathy | Charge | Polarity | Mutability |
|---|
| Ion channel |
| Name | Description |
|---|
| There are no data to be displayed... | |
| Gene | MCOLN3 | |
| PDB ID | 5W3S | |
| Protein Name | ||
| Cryo-electron microscopy structure of a TRPML3 ion channel | ||
| Organism | ||
| Callithrix jacchus | ||
| Receptor Name | Transient receptor potential cation channel, mucolipin subfamily, member 3 | |
| UniProt ID | F6RG56 | |
| Function | ||
| Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events (PubMed:29019979). Acts as Ca2+-permeable cation channel with inwardly rectifying activity (By similarity). Mediates release of Ca2+ from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca2+ for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (By similarity). | ||
| Activity regulation | ||
| Channel activity is activated by PtdIns(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) (PubMed:29019979). Inhibited by lumenal H+ and Na+. The channel pore shows dynamic behavior and undergoes spontaneous, Ca2+-dependent modulation when conducting Ca2+. | ||
| PID | Structure | Name | Source pungent TCM | FEMA or pubchemCID | Reference | ||
|---|---|---|---|---|---|---|---|
| No Result | |||||||