| Name | Length | Bottleneck | Hydropathy | Charge | Polarity | Mutability |
|---|
| Ion channel |
| Name | Description |
|---|
| There are no data to be displayed... | |
| Gene | TRPV4 | |
| PDB ID | 3W9F | |
| Protein Name | ||
| Crystal structure of the ankilin repeat domain of chicken TRPV4 in complex with IP3 | ||
| Organism | ||
| Gallus gallus | ||
| Receptor Name | Transient receptor potential cation channel subfamily V member 4 | |
| UniProt ID | A0A1D5PXA5 | |
| Function | ||
| Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11081638). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:11081638). Also activated by phorbol esters (PubMed:19864432). Channel activity seems to be regulated by a calmodulin-dependent mechanism (By similarity). | ||
| Activity regulation | ||
| ATP binding enhances channel sensitivity to agonists. Ca2+-calmodulin prevents the ATP-mediated increased sensitivity to agonists. | ||
| PID | Structure | Name | Source pungent TCM | FEMA or pubchemCID | Reference | ||
|---|---|---|---|---|---|---|---|
| No Result | |||||||