| Name | Length | Bottleneck | Hydropathy | Charge | Polarity | Mutability |
|---|
| Ion channel |
| Name | Description |
|---|
| There are no data to be displayed... | |
| Gene | Trpm7 | |
| PDB ID | 3E7K | |
| Protein Name | ||
| Crystal Structure of an antiparallel coiled-coil tetramerization domain from TRPM7 channels | ||
| Organism | ||
| Rattus norvegicus | ||
| Receptor Name | Transient receptor potential cation channel subfamily M member 7 | |
| UniProt ID | Q925B3 | |
| Function | ||
| Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1) (By similarity). | ||
| Activity regulation | ||
| ATP + L-threonyl-[protein] = ADP + H+ + O-phospho-L-threonyl-[protein] | ||
| PID | Structure | Name | Source pungent TCM | FEMA or pubchemCID | Reference | ||
|---|---|---|---|---|---|---|---|
| No Result | |||||||