LiteMol

Transient receptor potential cation channel family information

Name	Length	Bottleneck	Hydropathy	Charge	Polarity	Mutability

Ion channel

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Protein annotations

Gene	Trpv6
PDB ID	2RFA
Protein Name
Crystal structure of the mouse TRPV6 ankyrin repeat domain
Organism
Mus musculus
Receptor Name	Transient receptor potential cation channel subfamily V member 6
UniProt ID	Q91WD2
Function
Calcium selective cation channel that mediates Ca2+ uptake in various tissues, including the intestine (PubMed:12765696, PubMed:12601087, PubMed:12574114, PubMed:14736889, PubMed:15123711, PubMed:17129178). Important for normal Ca2+ ion homeostasis in the body, including bone and skin (PubMed:17129178, PubMed:22878123). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca2+-dependent and a slower Ca2+-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation (PubMed:15123711). In vitro, is slowly inhibited by Mg2+ in a voltage-independent manner (PubMed:12601087). Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114).
Activity regulation
No data available

Ligand List of this Receptor