Name | Length | Bottleneck | Hydropathy | Charge | Polarity | Mutability |
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Ion channel |
Name | Description |
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There are no data to be displayed... | |
Gene | Trpm7 | |
PDB ID | 1IAH | |
Protein Name | ||
Crystal structure of the atypical protein kinase domain of A TRP Ca-channel, Chak (Adp-Mg Complex) | ||
Organism | ||
Mus musculus | ||
Receptor Name | Transient receptor potential cation channel subfamily M member 7 | |
UniProt ID | Q923J1 | |
Function | ||
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). | ||
Activity regulation | ||
ATP + L-threonyl-[protein] = ADP + H+ + O-phospho-L-threonyl-[protein] | ||
PID | Structure | Name | Source pungent TCM | FEMA or pubchemCID | Reference | ||
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No Result |