Organ Location Map/System Distribution of Pungent Flavor Compounds’ Targets

Diallyl trisulfide (DATS), also known as Allitridin, is an organosulfur compound with the formula S(SCH2CH=CH2)2. It is one of several produced by the hydrolysis of allicin, including diallyl disulfide and diallyl tetrasulfide, DATS is one of the most poten.Diallyl trisulfide (DATS), the major compound in garlic oil, is obtained from freshly crushed garlic cloves. Diallyl trisulfide (DATS) is the principle component of garlic oil that possesses antioxidant properties.

Diallyl trisulfde (DTS) and diallyl disulfde (DDS) are the most abundant volatile sulfur-containing compounds in garlic oil. Diallyl trisulfide DATS) are volatile compounds produced when garlic bulb is cut and have been reported to inhibit carcinogenesis. Diallyl trisulfide (DATS), are characteristic flavor components of the essential oil prepared from garlic. Diallyl trisulfde (DATS), which is one of the major organosulfur compounds in garlic oil, has received considerable attention for its anti-cancer e?ects.

1. https://en.wikipedia.org/wiki/Diallyl_trisulfide

2. Liu, C. T., Hse, H., Lii, C. K., Chen, P. S., Sheen, L. Y. Effects of garlic oil and diallyl trisulfide on glycemic control in diabetic rats[J]. European journal of pharmacology, 2005, 516(2): 165-173.

3. Shaaban A A, El-Agamy D S. Cytoprotective effects of diallyl trisulfide against valproate-induced hepatotoxicity: new anticonvulsant strategy[J]. Naunyn-Schmiedeberg's archives of pharmacology, 2017, 390(9): 919-928.

4. Chan K, Yin M, Chao W. Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats[J]. Food and chemical toxicology, 2007, 45(3): 502-507.

5. Chen, H., Zhu, W., Feng, J., & Li, S. Protective effect of diallyl trisulfide on liver in rats with sepsis and the mechanism[J]. Journal of Huazhong University of Science and Technology [Medical Sciences], 2012, 32(5): 657-662.

6. Chen, L. Y., Chen, Q., Cheng, Y. F., Jin, H. H., Kong, D. S., Zhang, F., Zheng, S. Z. Diallyl trisulfide attenuates ethanol-induced hepatic steatosis by inhibiting oxidative stress and apoptosis[J]. Biomedicine & Pharmacotherapy, 2016, 79: 35-43.

7. Choi Y H, Park H S. Apoptosis induction of U937 human leukemia cells by diallyl trisulfide induces through generation of reactive oxygen species[J]. Journal of biomedical science, 2012, 19(1): 50.

8. Hosono-Fukao, T., Hosono, T., Seki, T., Ariga, T. Diallyl trisulfide protects rats from carbon tetrachloride-induced liver injury[J]. The Journal of nutrition, 2009, 139(12): 2252-2256.

9. Huang, Y. T., Yao, C. H., Way, C. L., Lee, K. W., Tsai, C. Y., Ou, H. C., Kuo, W. W. Diallyl trisulfide and diallyl disulfide ameliorate cardiac dysfunction by suppressing apoptotic and enhancing survival pathways in experimental diabetic rats[J]. Journal of applied physiology, 2012, 114(3): 402-410.

10. Lee, H. H., Han, M. H., Hwang, H. J., Kim, G. Y., Moon, S. K., Hyun, J. W., Choi, Y. H. Diallyl trisulfide exerts anti-inflammatory effects in lipopolysaccharide?stimulated RAW 264.7 macrophages by suppressing the Toll?like receptor 4/nuclear factor-B pathway[J]. International journal of molecular medicine, 2015, 35(2): 487-495.

11. Predmore, B. L., Grinsfelder, D. B., Aragon, J. P., Elston, M., Calvert, J. W., Lefer, D. J. The stable hydrogen sulfide donor, diallyl trisulfide, protects against acute myocardial infarction in mice[J]. Journal of the American College of Cardiology, 2010, 55(10 Supplement): A116. E1089.

12. Seki, T., Hosono, T., Hosono-Fukao, T., Inada, K., Tanaka, R., Ogihara, J., Ariga, T. Anticancer effects of diallyl trisulfide derived from garlic[J]. Asia Pacific Journal of Clinical Nutrition, 2008, 17(S1): 249-252.

13. Sumedha N C, Miltonprabu S. Diallyl trisulfide ameliorates arsenic-induced hepatotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats[J]. Human & experimental toxicology, 2015, 34(5): 506-525.

14. Wu, C. C., Lii, C. K., Tsai, S. J., Sheen, L. Y. Diallyl trisulfide modulates cell viability and the antioxidation and detoxification systems of rat primary hepatocytes[J]. The Journal of nutrition, 2004, 134(4): 724-728.

15. Xu, X. H., Li, G. L., Wang, B. A., Qin, Y., Bai, S. R., Rong, J., Li, Q. Diallyl trisufide protects against oxygen glucose deprivation-induced apoptosis by scavenging free radicals via the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway in B35 neural cells[J]. Brain research, 2015, 1614: 38-50.

16. Zeng, T., Zhang, C. L., Zhu, Z. P., Yu, L. H., Zhao, X. L., Xie, K. Q. Diallyl trisulfide (DATS) effectively attenuated oxidative stress-mediated liver injury and hepatic mitochondrial dysfunction in acute ethanol-exposed mice[J]. Toxicology, 2008, 252(1-3): 86-91.

17. Yu, L., Li, S., Tang, X., Li, Z., Zhang, J., Xue, X., Xu, Y. Diallyl trisulfide ameliorates myocardial ischemiaCreperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 activation[J]. Apoptosis, 2017, 22(7): 942-954.

18. Li, W. R., Shi, Q. S., Dai, H. Q., Liang, Q., Xie, X. B., Huang, X. M., Zhang, L. X. Antifungal activity, kinetics and molecular mechanism of action of garlic oil against Candida albicans[J]. Scientific reports, 2016, 6: 22805.

19. Calvo-Gmez O, Morales-Lpez J, Lpez M G. Solid-phase microextractionCgas chromatographicCmass spectrometric analysis of garlic oil obtained by hydrodistillation[J]. Journal of Chromatography A, 2004, 1036(1): 91-93.

20. Li, W. R., Shi, Q. S., Liang, Q., Huang, X. M., Chen, Y. B. Antifungal effect and mechanism of garlic oil on Penicillium funiculosum[J]. Applied microbiology and biotechnology, 2014, 98(19): 8337-8346.

21. Wargovich M J. Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethyihydrazine-induced colon cancer[J]. Carcinogenesis, 1987, 8(3): 487-489.

22. Wattenberg L W, Sparnins V L, Barany G. Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes[J]. Cancer research, 1989, 49(10): 2689-2692.

23. Hosono, T., Fukao, T., Ogihara, J., Ito, Y., Shiba, H., Seki, T., Ariga, T. Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of -tubulin[J]. Journal of Biological Chemistry, 2005.

24. Hong, J. Y., Wang, Z. Y., Smith, T. J., Zhou, S., Shi, S., Pan, J., Yang, C. S Inhibitory effects of diallyl sulfide on the metabolism and tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mouse lung[J]. Carcinogenesis, 1992, 13(5): 901-904.

25. Reddy B S, Rao C V, Rivenson A, et al. Chemoprevention of colon carcinogenesis by organosulfur compounds[J]. Cancer Research, 1993, 53(15): 3493-3498.

26. Sparnins V L, Barany G, Wattenberg L W. Effects of organosulfur compounds from garlic and onions on benzo [a] pyrene-induced neoplasia and glutathione S-transferase activity in the mouse[J]. Carcinogenesis, 1988, 9(1): 131-134.

27. Wargovich, M. J., Woods, C., Eng, V. W., Stephens, L. C., Gray, K. Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallyl sulfide[J]. Cancer Research, 1988, 48(23): 6872-6875.

28. Herman-Antosiewicz A, Singh S V. Checkpoint kinase 1 regulates diallyl trisulfide-induced mitotic arrest in human prostate cancer cells[J]. Journal of Biological Chemistry, 2005, 280(31): 28519-28528.

29. Kim, Y. A., Xiao, D., Xiao, H., Powolny, A. A., Lew, K. L., Reilly, M. L., Singh, S. V. Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak[J]. Molecular cancer therapeutics, 2007, 6(5): 1599-1609.

30. Powolny A A, Singh S V. Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds[J]. Cancer letters, 2008, 269(2): 305-314.

31. Xiao, D., Choi, S., Johnson, D. E., Vogel, V. G., Johnson, C. S., Trump, D. L., Singh, S. V. Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2[J]. Oncogene, 2004, 23(33): 5594.

32. Xiao, D., Zeng, Y., Hahm, E. R., Kim, Y. A., Ramalingam, S., Singh, S. V. Diallyl trisulfide selectively causes Bax\and Bak\mediated apoptosis in human lung cancer cells[J]. Environmental and molecular mutagenesis, 2009, 50(3): 201-212.

33. Tsai, C. Y., Wang, C. C., Lai, T. Y., Tsu, H. N., Wang, C. H., Liang, H. Y., Kuo, W. W. Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes[J]. International journal of cardiology, 2013, 168(2): 1286-1297.

34. Predmore, B. L., Kondo, K., Bhushan, S., Zlatopolsky, M. A., King, A. L., Aragon, J. P., Lefer, D. J. The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability[J]. American Journal of Physiology-Heart and Circulatory Physiology, 2012, 302(11): H2410-H2418.

35. Zhu, X., Zhang, F., Zhou, L., Kong, D., Chen, L., Lu, Y., Zheng, S. Diallyl trisulfide attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic oxidative stress in rats[J]. Naunyn-Schmiedeberg's archives of pharmacology, 2014, 387(5): 445-455.

36. Zeng, T., Zhang, C. L., Zhu, Z. P., Yu, L. H., Zhao, X. L., Xie, K. Q. Diallyl trisulfide (DATS) effectively attenuated oxidative stress-mediated liver injury and hepatic mitochondrial dysfunction in acute ethanol-exposed mice[J]. Toxicology, 2008, 252(1-3): 86-91.

37. Na, H. K., Kim, E. H., Choi, M. A., Park, J. M., Kim, D. H., Surh, Y. J. Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1[J]. Biochemical pharmacology, 2012, 84(10): 1241-1250.

38. Shrotriya, S., Kundu, J. K., Na, H. K., Surh, Y. J. Diallyl Trisulfide Inhibits Phorbol EsterCInduced Tumor Promotion, Activation of AP-1, and Expression of COX-2 in Mouse Skin by Blocking JNK and Akt Signaling[J]. Cancer research, 2010: 0008-5472. CAN-09-3501.

39. Xiao, D., Li, M., Herman-Antosiewicz, A., Antosiewicz, J., Xiao, H., Lew, K. L., Singh, S. V. Diallyl trisulfide inhibits angiogenic features of human umbilical vein endothelial cells by causing Akt inactivation and down-regulation of VEGF and VEGF-R2[J]. Nutrition and cancer, 2006, 55(1): 94-107.

40. Singh, S. V., Powolny, A. A., Stan, S. D., Xiao, D., Arlotti, J. A., Warin, R., Dhir, R. Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice[J]. Cancer research, 2008, 68(22): 9503-9511.

41. Li, W., Tian, H., Li, L., Li, S., Yue, W., Chen, Z., Gao, C. Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo[J]. Acta Biochim Biophys Sin, 2012, 44(7): 577-583.

42. Wu, P. P., Liu, K. C., Huang, W. W., Chueh, F. S., Ko, Y. C., Chiu, T. H., Chung, J. G. Diallyl trisulfide (DATS) inhibits mouse colon tumor in mouse CT-26 cells allograft model in vivo[J]. Phytomedicine, 2011, 18(8-9): 672-676.

43. Zhang, Z. M., Yang, X. Y., Deng, S. H., Wei, X., Gao, H. Q. Anti-tumor effects of polybutylcyanoacrylate nanoparticles of diallyl trisulfide on orthotopic transplantation tumor model of hepatocellular carcinoma in BALB/c nude mice[J]. Chinese medical journal, 2007, 120(15): 1336-1342.

44. Malki A, El-Saadani M, Sultan A S. Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells[J]. Cancer biology & therapy, 2009, 8(22): 2174-2184.

45. Kim YA, Xiao D, Xiao H, Powolny AA, Lew KL, Reilly ML, et al. Mitochondriamediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak. Mol Cancer Ther 2007;6:1599C609

46. Nakagawa, H., Tsuta, K., Kiuchi, K., Senzaki, H., Tanaka, K., Hioki, K., Tsubura, A.Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines[J]. Carcinogenesis, 2001, 22(6): 891-897.

47. Xiao D, Singh S V. Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells[J]. Carcinogenesis, 2005, 27(3): 533-540.

48. Lee, B. C., Park, B. H., Kim, S. Y., Lee, Y. J. Role of Bim in diallyl trisulfide\induced cytotoxicity in human cancer cells[J]. Journal of cellular biochemistry, 2011, 112(1): 118-127.

49. Wang, H. C., Hsieh, S. C., Yang, J. H., Lin, S. Y., Sheen, L. Y. Diallyl trisulfide induces apoptosis of human basal cell carcinoma cells via endoplasmic reticulum stress and the mitochondrial pathway[J]. Nutrition and cancer, 2012, 64(5): 770-780.

50. Antosiewicz, J., Herman-Antosiewicz, A., Marynowski, S. W., Singh, S. V. C-Jun NH2-terminal kinase signaling axis regulates diallyl trisulfideCinduced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells[J]. Cancer research, 2006, 66(10): 5379-5386.

51. Wang, Y. B., Qin, J., Zheng, X. Y., Bai, Y., Yang, K., Xie, L. P. Diallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cells[J]. Phytomedicine, 2010, 17(5): 363-368.

52. Xiao, D., Lew, K. L., Kim, Y. A., Zeng, Y., Hahm, E. R., Dhir, R., Singh, S. V. Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction[J]. Clinical Cancer Research, 2006, 12(22): 6836-6843.

53. Li, Y., Zhang, J., Zhang, L., Si, M., Yin, H., Li, J. Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling[J]. Carcinogenesis, 2013, 34(7): 1601-1610.

54. Herman-Antosiewicz, A., Stan, S. D., Hahm, E. R., Xiao, D., & Singh, S. V. Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1Cdependent prometaphase checkpoint in cancer cells by diallyl trisulfide, a promising cancer chemopreventive constituent of processed garlic[J]. Molecular cancer therapeutics, 2007, 6(4): 1249-1261.

55. Ma, H. B., Huang, S., Yin, X. R., Zhang, Y., Di, Z. L. Apoptotic pathway induced by diallyl trisulfide in pancreatic cancer cells[J]. World Journal of Gastroenterology: WJG, 2014, 20(1): 193.

56. Pan Y, Lin S, Xing R, et al. Epigenetic upregulation of metallothionein 2A by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel through attenuating NF-B activation[J]. Antioxidants & redox signaling, 2016, 24(15): 839-854.

57. Shin, D. Y., Cha, H. J., Kim, G. Y., Kim, W. J., Choi, Y. H. Inhibiting invasion into human bladder carcinoma 5637 cells with diallyl trisulfide by inhibiting matrix metalloproteinase activities and tightening tight junctions[J]. International journal of molecular sciences, 2013, 14(10): 19911-19922.

58. Shin, D. Y., Kim, G. Y., Hwang, H. J., Kim, W. J., Choi, Y. H Diallyl trisulfide-induced apoptosis of bladder cancer cells is caspase-dependent and regulated by PI3K/Akt and JNK pathways[J]. Environmental toxicology and pharmacology, 2014, 37(1): 74-83.

59. Wan, H. F., Yu, L. H., Wu, J. L., Tu, S., Zhu, W. F., Zhang, X. L., Wan, F. S. Effect of diallyl trisulfide on human ovarian cancer SKOV-3/DDP cell apoptosis[J]. Asian Pacific Journal of Cancer Prevention, 2013, 14(12): 7197-7201.

60. Xiao, D., Herman-Antosiewicz, A., Antosiewicz, J., Xiao, H., Brisson, M., Lazo, J. S., Singh, S. V. Diallyl trisulfide-induced G 2CM phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc25C[J]. Oncogene, 2005, 24(41): 6256.

61. Liu, C., Leng, B., Li, Y., Jiang, H., Duan, W., Guo, Y., Hong, K. Diallyl Trisulfide Protects Motor Neurons from the Neurotoxic Protein TDP-43 via Activating Lysosomal Degradation and the Antioxidant Response[J]. Neurochemical research, 2018, 43(12): 2304-2312.

62. Sun, M. M., Bu, H., Li, B., Yu, J. X., Guo, Y. S., Li, C. Y. Neuroprotective potential of phase II enzyme inducer diallyl trisulfide[J]. Neurological research, 2009, 31(1): 23-27.

63. Lee, H. J., Lee, H. G., Choi, K. S., Surh, Y. J., Na, H. K. Diallyl trisulfide suppresses dextran sodium sulfate-induced mouse colitis: NF-B and STAT3 as potential targets[J]. Biochemical and biophysical research communications, 2013, 437(2): 267-273.

64. Wu, C. C., Chung, J. G., Tsai, S. J., Yang, J. H., Sheen, L. Y. Differential effects of allyl sulfides from garlic essential oil on cell cycle regulation in human liver tumor cells[J]. Food and Chemical Toxicology, 2004, 42(12): 1937-1947.

65. Antony M L, Singh S V. Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide[J]. Indian journal of experimental biology, 2011, 49(11): 805.

66. Lai, K. C., Kuo, C. L., Ho, H. C., Yang, J. S., Ma, C. Y., Lu, H. F., Chung, J. G. Diallyl sulfide, diallyl disulfide and diallyl trisulfide affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo[J]. Phytomedicine, 2012, 19(7): 625-630.

67. Liu, K. L., Chen, H. W., Wang, R. Y., Lei, Y. P., Sheen, L. Y., Lii, C. K. DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-B activation in RAW 264.7 macrophages[J]. Journal of agricultural and food chemistry, 2006, 54(9): 3472-3478.

68. Chandra-Kuntal K, Singh S V. Diallyl trisulfide inhibits activation of signal transducer and activator of transcription 3 in prostate cancer cells in culture and in vivo[J]. Cancer prevention research, 2010: 1940-6207. CAPR-10-0123.

69. Stan, S. D., Kar, S., Stoner, G. D., Singh, S. V. Bioactive food components and cancer risk reduction[J]. Journal of cellular biochemistry, 2008, 104(1): 339-356.

70. Kim, S. H., Kaschula, C. H., Priedigkeit, N., Lee, A. V., Singh, S. V. Forkhead box Q1 is a novel target of breast cancer stem cell inhibition by diallyl trisulfide[J]. Journal of Biological Chemistry, 2016: jbc. M116. 715219.

71. Hahm E R, Singh S V. Diallyl trisulfide inhibits estrogen receptor- activity in human breast cancer cells[J]. Breast cancer research and treatment, 2014, 144(1): 47-57.

72. Chandra-Kuntal K, Lee J, Singh S V. Critical role for reactive oxygen species in apoptosis induction and cell migration inhibition by diallyl trisulfide, a cancer chemopreventive component of garlic[J]. Breast cancer research and treatment, 2013, 138(1): 69-79.

73. Liu, Y., Zhu, P., Wang, Y., Wei, Z., Tao, L., Zhu, Z., Cao, Y. Antimetastatic therapies of the polysulfide diallyl trisulfide against triple-negative breast cancer (TNBC) via suppressing MMP2/9 by blocking NF-B and ERK/MAPK signaling pathways[J]. PloS one, 2015, 10(4): e0123781.

74. Sun, X., Guo, T., He, J., Zhao, M., Yan, M., Cui, F., Deng, Y. Determination of the concentration of diallyl trisulfide in rat whole blood using gas chromatography with electron-capture detection and identification of its major metabolite with gas chromatography mass spectrometry[J]. Yakugaku Zasshi, 2006, 126(7): 521-527.

75. Kiesel V A, Stan S D. Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells[J]. Biochemical and biophysical research communications, 2017, 484(4): 833-838.

76. Szabo C. Gasotransmitters in cancer: from pathophysiology to experimental therapy[J]. Nature Reviews Drug Discovery, 2016, 15(3): 185.

77. Qi, R., Liao, F., Inoue, K., Yatomi, Y., Sato, K., Ozaki, Y. Inhibition by diallyl trisulfide, a garlic component, of intracellular Ca2+ mobilization without affecting inositol-1, 4, 5-trisphosphate (IP3) formation in activated platelets[J]. Biochemical pharmacology, 2000, 60(10): 1475-1483.

78. Nelson, E. C., Evans, C. P., Mack, P. C., Devere-White, R. W., Lara Jr, P. N. Inhibition of Akt pathways in the treatment of prostate cancer[J]. Prostate cancer and prostatic diseases, 2007, 10(4): 331.

79. Powolny, A. A., Singh, S. V., Melov, S., Hubbard, A., Fisher, A. L. The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation[J]. Experimental gerontology, 2011, 46(6): 441-452.

80. Ogawa, T., Kodera, Y., Hirata, D., Blackwell, T. K., Mizunuma, M. Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf[J]. Scientific reports, 2016, 6: 21611.

81. Wei Z, Lu Y. P4 Diallyl Trisulfides, a garlic-derived organosulfur compound, attenuates vascular metastasis of hypoxic breast cancer cells by targeting the thioredoxin system[J]. Biochemical Pharmacology, 2017, 139: 125-126.

82. Suchal, K., Malik, S., Khan, S. I., Malhotra, R. K., Goyal, S. N., Bhatia, J., Arya, D. S. Protective effect of mangiferin on myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats: role of AGE-RAGE/MAPK pathways[J]. Scientific reports, 2017, 7: 42027.

83. Kuo, W. W., Wang, W. J., Tsai, C. Y., Way, C. L., Hsu, H. H., Chen, L. M. Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFB signaling via attenuating ROS generation[J]. International journal of cardiology, 2013, 168(1): 270-280

84. Block E. Garlic and other Alliums: the lore and the science[M]. Royal society of Chemistry, 2010.