2D Structure
3D Structure
| Properties | |
|---|---|
| PID | PID00004 |
| Mol. Weight | 285.343 g/mol |
| LogP | 2.78 |
| Water solubility | 0.04 mg/mL at 18 °C |
| Hydrogen Bond Donor | 0 |
| Hydrogen Bond Acceptor | 3 |
| Rotatable Bonds | 3 |
| XLogP3 | 3.5 |
| Identifiers | |
|---|---|
| Formula | C17H19NO3 |
| PubChem CID | 638024 |
| FEMA | 2909 |
| Flavor Profile | Spice,pungency |
| Smiles | C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3 |
| InChl Key | MXXWOMGUGJBKIW-YPCIICBESA-N |
| InChl | InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+ |
| CAS Registry Number | 94-62-2 |
| IUPAC Systematic Name | (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one |
Organ Location Map/System Distribution of Pungent Flavor Compounds’ Targets
Note: Known Targets (Gene) from 6952 literatures, DrugBank (http://www.drugbank.ca/), STITCH (http://stitch.embl.de/), ChEMBL (https://www.ebi.ac.uk/chembl/), Therapeutic Target Database (http://bidd.nus.edu.sg/group/ttd/), and Comparative Toxicogenomics Database (CTD, http://ctdbase.org/)
| English Name | Pinyin Name (Chinese Name) | Latin Name | Properties in TCM | merdians | View Graph |
|---|---|---|---|---|---|
| Black Pepper | Hu Jiao (胡椒) | Piperis Fructus | Hot,Pungent | Large Intestine, Stomach | View Graph |
| Long Pepper | Bi Ba (荜茇) | Piperis Longi Fructus | Hot,Pungent | Large Intestine, Stomach | View Graph |
Piperine is known to possess anti-inflammatory activity, antipyretic activity, antifungal activity, antidiarrheal activity, antioxidant activity,
antithyroid activity, antimutagenic activity, antitumor activity, antidepressant activity, analgesic activity, hepatoprotective activity, antihypertensive
activity, hypolipidemic effect, neuroprotective effect etc.
Note: Click anywhere in the blank, you can drag the whole dynamic diagram. Click on a node, you can drag his location to see it more clearly. The blue circle represents pharmacology, toxicology, or daily use. Orange hexagon represents the pungent compounds.
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40. Jwa H, Choi Y, Park U H, et al. Piperine, an LXR antagonist, protects against hepatic steatosis and improves insulin signaling in mice fed a high-fat dietJ.. Biochemical pharmacology, 2012, 84(11): 1501-1510.
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43. Lai L, Fu Q, Liu Y, et al. Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer modelJ.. Acta Pharmacologica Sinica, 2012, 33(4): 523.
44. Liu Y, Zhang Y, Lin K, et al. Protective effect of piperine on electrophysiology abnormalities of left atrial myocytes induced by hydrogen peroxide in rabbitsJ.. Life sciences, 2014, 94(2): 99-105.
45. Selvendiran K, Senthilnathan P, Magesh V, et al. Modulatory effect of Piperine on mitochondrial antioxidant system in Benzo (a) pyrene-induced experimental lung carcinogenesisJ.. Phytomedicine, 2004, 11(1): 85.
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