2D Structure
3D Structure
| Properties | |
|---|---|
| PID | PID00033 |
| Mol. Weight | 152.237 g/mol |
| LogP | 2.86 |
| Water solubility | In water, 276 mg/L at 25 °C (est) |
| Hydrogen Bond Donor | 0 |
| Hydrogen Bond Acceptor | 1 |
| Rotatable Bonds | 0 |
| XLogP3-AA | 2.8 |
| Identifiers | |
|---|---|
| Formula | C10H16O |
| PubChem CID | 6988 |
| FEMA | 2963 |
| Flavor Profile | None |
| Smiles | CC(C)=C1CCC(C)CC1=O |
| InChl Key | NZGWDASTMWDZIW-UHFFFAOYSA-N |
| InChl | InChI=1S/C10H16O/c1-7(2)9-5-4-8(3)6-10(9)11/h8H,4-6H2,1-3H3 |
| CAS Registry Number | 15932-80-6 |
| IUPAC Systematic Name | 5-methyl-2-propan-2-ylidenecyclohexan-1-one |
Organ Location Map/System Distribution of Pungent Flavor Compounds’ Targets
Note: Known Targets (Gene) from 6952 literatures, DrugBank (http://www.drugbank.ca/), STITCH (http://stitch.embl.de/), ChEMBL (https://www.ebi.ac.uk/chembl/), Therapeutic Target Database (http://bidd.nus.edu.sg/group/ttd/), and Comparative Toxicogenomics Database (CTD, http://ctdbase.org/)
| English Name | Pinyin Name (Chinese Name) | Latin Name | Properties in TCM | merdians | View Graph |
|---|---|---|---|---|---|
| Siebold Wildginger Equivalent plant: Asarum hetero | Xi Xin (细辛) | Asari Radix Et Rhizoma | Warm, Pungent | Lung, Spleen, Stomach | View Graph |
| Fineleaf Schizonepeta | Jing Jie (荆芥) | Schizonepetae Herba | Minor Warm, Pungent | Lung, Liver | View Graph |
| Chinese Clematis | Wei Ling Xian (威灵仙) | Clematidis Radix Et Rhizoma | Warm, Pungent, Salty | Bladder | View Graph |
| Haichow Elsholtzia | Xiang Ru (香薷) | Moslae Herba | Minor Warm,Pungent | Lung, Spleen, Stomach | View Graph |
| Shorthorned Epimedium Equivalent plant: Epimedium | Yin Yang Huo (淫羊藿) | Epimedii Folium | Warm, Sweet, Pungent | Liver, Kidney | View Graph |
| Wild Mint | Bo He (薄荷) | Menthae Haplocalycis Herba | Cool, Pungent | Liver, Lung | View Graph |
| Bugbane Equivalent plant: Cimicifuga dahurica, Ci | Sheng Ma(升麻) | Cimicifugae Rhizoma | Cold, Sweet, Pungent | Lung, Spleen, Large Intestine, Stomach | View Graph |
| Chinese Thorowax Equivalent plant: Bupleurum scorz | Chai Hu(柴胡) | Bupleuri Radix | Minor cold, Pungent, Bitter | Liver, Gallbladder, Lung | View Graph |
| Asiatic Pennywort | Ji Xue Cao (积雪草) | Centellae Herba | Cold, Sweet, Bitter | Liver, Spleen, Kidney | View Graph |
| Chinese Ephedra Equivalent plant: Ephedra equiseti | Ma Huang (麻黄) | Ephedrae Herba | Warm, Pungent, Slightly Bitter | Lung, Bladder | View Graph |
Pulegone is a clear colorless oily liquid and has a pleasant odor similar to pennyroyal, peppermint and camphor. It is used in flavoring agents,
in perfumery, and in aromatherapy.
Note: Click anywhere in the blank, you can drag the whole dynamic diagram. Click on a node, you can drag his location to see it more clearly. The blue circle represents pharmacology, toxicology, or daily use. Orange hexagon represents the pungent compounds.
1. Vadiraja B B, Gaikwad N W, Madyastha K M. Hepatoprotective effect of C-Phycocyanin: protection for carbon tetrachloride andR-(+)-pulegone-mediated hepatotoxicty in rats[J]. Biochemical and Biophysical Research Communications, 1998, 249(2): 428-431.
2. Ghosh A, Nethery R C, Herring A H, et al. Flavored little cigar smoke induces cytotoxicity and apoptosis in airway epithelia[J]. Cell death discovery, 2017, 3: 17019.
3. Yeston J. Rapid ryanodol route[J]. 2016.
4. Ash C. A Flashy Affair[J]. Science, 2008, 319(5868): 1309-1309.
5. Liu Z, Zhao J, Li W, et al. Computational screen and experimental validation of anti-influenza effects of quercetin and chlorogenic acid from traditional Chinese medicine[J]. Scientific reports, 2016, 6: 19095.
6. Thorup I, Würtzen G, Carstensen J, et al. Short term toxicity study in rats dosed with pulegone and menthol[J]. Toxicology letters, 1983, 19(3): 207-210.
7. https://en.wikipedia.org/wiki/Pulegone