2D Structure
3D Structure
| Properties | |
|---|---|
| PID | PID00030 |
| Mol. Weight | 150.221 g/mol |
| LogP | 2.71 |
| Water solubility | In water, 367 mg/L at 25 °C (est) |
| Hydrogen Bond Donor | 0 |
| Hydrogen Bond Acceptor | 1 |
| Rotatable Bonds | 1 |
| XLogP3-AA | 2.4 |
| Identifiers | |
|---|---|
| Formula | C10H14O |
| PubChem CID | 439570 |
| FEMA | 2249 |
| Flavor Profile | A Sweetish Minty Smell, Like Spearmint Leaves |
| Smiles | C=C(C)[C@@H]1CC=C(C)C(=O)C1 |
| InChl Key | ULDHMXUKGWMISQ-SECBINFHSA-N |
| InChl | InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/m1/s1 |
| CAS Registry Number | 6485-40-1 |
| IUPAC Systematic Name | (5R)-2-methyl-5-prop-1-en-2-ylcyclohex-2-en-1-one |
Organ Location Map/System Distribution of Pungent Flavor Compounds’ Targets
Note: Known Targets (Gene) from 6952 literatures, DrugBank (http://www.drugbank.ca/), STITCH (http://stitch.embl.de/), ChEMBL (https://www.ebi.ac.uk/chembl/), Therapeutic Target Database (http://bidd.nus.edu.sg/group/ttd/), and Comparative Toxicogenomics Database (CTD, http://ctdbase.org/)
| English Name | Pinyin Name (Chinese Name) | Latin Name | Properties in TCM | merdians | View Graph |
|---|---|---|---|---|---|
| Siebold Wildginger Equivalent plant: Asarum hetero | Xi Xin (细辛) | Asari Radix Et Rhizoma | Warm, Pungent | Lung, Spleen, Stomach | View Graph |
| Chinese Thorowax Equivalent plant: Bupleurum scorz | Chai Hu(柴胡) | Bupleuri Radix | Minor cold, Pungent, Bitter | Liver, Gallbladder, Lung | View Graph |
| Round Cardamon Fruit | Dou Kou (豆蔻) | Amomi Fructus Rotundus | Warm, Pungent, | Spleen, Lung, Stomach | View Graph |
| bark of Officinal magnolia | Hou Pu(厚朴) | Magnoliae Officinalis Cortex | Warm, Pungent, Bitter | Spleen, Liver | View Graph |
| Black Pepper | Hu Jiao (胡椒) | Piperis Fructus | Hot,Pungent | Large Intestine, Stomach | View Graph |
| Fineleaf Schizonepeta | Jing Jie (荆芥) | Schizonepetae Herba | Minor Warm, Pungent | Lung, Liver | View Graph |
| Chinese Ephedra Equivalent plant: Ephedra equiseti | Ma Huang (麻黄) | Ephedrae Herba | Warm, Pungent, Slightly Bitter | Lung, Bladder | View Graph |
| Frankincense, Olibanum | Ru Xiang (乳香) | Olibanum | Warm,Bitter, Pungent | Spleen, Lung | View Graph |
| Villous Amomum Equivalent plant: Amomum xanthioide | Sha Ren (砂仁) | Amomi Fructus | Warm, Pungent | Lung, Spleen, Stomach | View Graph |
| Fresh Common Ginger | Sheng Jiang (生姜) | Zingiber Rhizoma Recens | Warm, Pungent | Lung, Spleen, Stomach | View Graph |
| Wild Mint | Bo He (薄荷) | Menthae Haplocalycis Herba | Cool, Pungent | Liver, Lung | View Graph |
| Divaricate Saposhnikovia | Fang Feng (防风) | Saposhnikoviae Radix | Warm, Pungent, Sweet | Lung, Bladder, Heart | View Graph |
| Dahurian Angelica | Bai Zhi(白芷) | Angelicae Dahuricae Radix | Warm, Pungent | Lung, Spleen, Stomach | View Graph |
| Illicium difengpi | Di Feng Pi(地枫皮) | Difengpi Anisetree Equivalent plant: Illicium maju | Warm,Slightly Pungent,Punkery | Bladder,Kidney | View Graph |
| Divaricate Saposhnikovia | Fang Feng (防风) | Saposhnikoviae Radix | Warm, Pungent, Sweet | Lung, Bladder, Heart | View Graph |
| Artemisia argyi | Ai Ye(艾叶) | Argy Wormwood Leaf Equivalent plant: Artemisia mon | Warm,Pungent,Bitter | Lung,Spleen,Liver | View Graph |
| Evodia rutaecarpa | Wu Zhu Yu(吴茱萸) | Medicinal Evodia Equivalent plant: Evodia rutaecar | Pungent, bitter, hot | Liver, spleen,stomach | View Graph |
l-Carvone is also formed as a minor product via reduction by NADPH. l-Carvone is likewise converted to (+)-carveol. This mainly occurs in the liver and
involves cytochrome P450 oxidase and (+)-trans-carveol dehydrogenase.
Note: Click anywhere in the blank, you can drag the whole dynamic diagram. Click on a node, you can drag his location to see it more clearly. The blue circle represents pharmacology, toxicology, or daily use. Orange hexagon represents the pungent compounds.
1 Gottfried J A. Central mechanisms of odour object perception[J]. Nature Reviews Neuroscience, 2010, 11(9): 628.
2 Kirner A, Deutsch S, Weiler E, et al. Concanavalin A application to the olfactory epithelium reveals different sensory neuron populations for the odour pair D-and L-carvone[J]. Behavioural brain research, 2003, 138(2): 201-206.
3 Lapid H, Shushan S, Plotkin A, et al. Neural activity at the human olfactory epithelium reflects olfactory perception[J]. Nature neuroscience, 2011, 14(11): 1455.
4 Weinstock R S, Wright H N, Spiegel A M, et al. Olfactory dysfunction in humans with deficient guanine nucleotide-binding protein[J]. Nature, 1986, 322(6080): 635-636.
5 Perez-Orive J, Mazor O, Turner G C, et al. Oscillations and sparsening of odor representations in the mushroom body[J]. Science, 2002, 297(5580): 359-365.
6 Edwards J G. TRPV1 in the central nervous system: synaptic plasticity, function, and pharmacological implications[M]//Capsaicin as a therapeutic molecule. Springer, Basel, 2014: 77-104.
7 Benemei S, Patacchini R, Trevisani M, et al. TRP channels[J]. Current opinion in pharmacology, 2015, 22: 18-23.
8 Sobel N, Khan R M, Saltman A, et al. Olfaction: the world smells different to each nostril[J]. Nature, 1999, 402(6757): 35.
9 Kirner A, Deutsch S, Weiler E, et al. Concanavalin A application to the olfactory epithelium reveals different sensory neuron populations for the odour pair D-and L-carvone[J]. Behavioural brain research, 2003, 138(2): 201-206.
10 https://en.wikipedia.org/wiki/Carvone