2D Structure
3D Structure
| Properties | |
|---|---|
| PID | PID00129 |
| Mol. Weight | 85.15 g/mol |
| LogP | 0.66 |
| Water solubility | 1.45 mol/L at 20 °C |
| Hydrogen Bond Donor | 1 |
| Hydrogen Bond Acceptor | 1 |
| Rotatable Bonds | 0 |
| XLogP3 | 0.8 |
| Identifiers | |
|---|---|
| Formula | C5H11N |
| PubChem CID | 8082 |
| FEMA | 2908 |
| Flavor Profile | Amine-Like Odor, Heavy, Sweet, Floral, Animal Odor, Odor Of Pepper; Burning Peppery Taste; Floral |
| Smiles | C1CCNCC1 |
| InChl Key | NQRYJNQNLNOLGT-UHFFFAOYSA-N |
| InChl | InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2 |
| CAS Registry Number | 110-89-4 |
| IUPAC Systematic Name | piperidine |
Organ Location Map/System Distribution of Pungent Flavor Compounds’ Targets
Note: Known Targets (Gene) from 6952 literatures, DrugBank (http://www.drugbank.ca/), STITCH (http://stitch.embl.de/), ChEMBL (https://www.ebi.ac.uk/chembl/), Therapeutic Target Database (http://bidd.nus.edu.sg/group/ttd/), and Comparative Toxicogenomics Database (CTD, http://ctdbase.org/)
| English Name | Pinyin Name (Chinese Name) | Latin Name | Properties in TCM | merdians | View Graph |
|---|---|---|---|---|---|
| Long Pepper | Bi Ba (荜茇) | Piperis Longi Fructus | Hot,Pungent | Large Intestine, Stomach | View Graph |
| Black Pepper | Hu Jiao (胡椒) | Piperis Fructus | Hot,Pungent | Large Intestine, Stomach | View Graph |
| Bush Redpepper | La Jiao (辣椒) | Capsici Fructus | Hot, Pungent | Lung, Spleen, Stomach, Heart, Kidney | View Graph |
Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene
bridges (CCH2C) and one amine bridge (CNHC). It is a colorless liquid with an odor described as objectionable, and typical of amines.
Piperidine itself has been obtained from black pepper, from Psilocaulon absimile (Aizoaceae), and in Petrosimonia monandra.
Note: Click anywhere in the blank, you can drag the whole dynamic diagram. Click on a node, you can drag his location to see it more clearly. The blue circle represents pharmacology, toxicology, or daily use. Orange hexagon represents the pungent compounds.
1. https://en.wikipedia.org/wiki/Piperidine
2. Späth, Ernst, and Georg Englaender. Über das Vor‐kommen von Piperidin im schwarzen Pfeffer. Berichte der deutschen chemischen Gesellschaft (A and B Series) 68.12 (1935): 2218-2221.
3. Pictet, Amé, and René Pictet. Sur l'alcaloïde volatil du poivre. Helvetica Chimica Acta 10.1 (1927): 593-595.
4. Rimington, Claude. Psilocaulon absimile NE Br. As a stock poison. South African Journal of Science 31.07 (1934): 184-193.
5. Yurashevskii N K, Stepanov S I. The alkaloids: Chemistry and Physiology[J]. J. Gen. Chem. USSR, 1939, 9: 1687.
6. Johnson D S, Ahn K, Kesten S, et al. Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)[J]. Bioorganic & medicinal chemistry letters, 2009, 19(10): 2865-2869.
7. Corminboeuf O, Bezençon O, Grisostomi C, et al. Design and optimization of new piperidines as renin inhibitors[J]. Bioorganic & medicinal chemistry letters, 2010, 20(21): 6286-6290.