data_2ETC # _entry.id 2ETC # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 2ETC RCSB RCSB035067 WWPDB D_1000035067 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 2ETA 'Crystal structure of the ankyrin repeat domain of TRPV2' unspecified PDB 2ETB 'Crystal structure of the ankyrin repeat domain of TRPV2' unspecified PDB 2ET9 'Crystal structure of the ankyrin repeat domain of TRPV1' unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 2ETC _pdbx_database_status.recvd_initial_deposition_date 2005-10-27 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_cs ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Jin, X.' 1 'Gaudet, R.' 2 # _citation.id primary _citation.title 'Structure of the N-terminal Ankyrin Repeat Domain of the TRPV2 Ion Channel.' _citation.journal_abbrev J.Biol.Chem. _citation.journal_volume 281 _citation.page_first 25006 _citation.page_last 25010 _citation.year 2006 _citation.journal_id_ASTM JBCHA3 _citation.country US _citation.journal_id_ISSN 0021-9258 _citation.journal_id_CSD 0071 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 16809337 _citation.pdbx_database_id_DOI 10.1074/jbc.C600153200 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Jin, X.' 1 primary 'Touhey, J.' 2 primary 'Gaudet, R.' 3 # _cell.entry_id 2ETC _cell.length_a 39.514 _cell.length_b 95.862 _cell.length_c 164.504 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 8 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 2ETC _symmetry.space_group_name_H-M 'P 21 21 21' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 19 _symmetry.space_group_name_Hall ? # _entity.id 1 _entity.type polymer _entity.src_method man _entity.pdbx_description 'Transient receptor potential cation channel subfamily V member 2' _entity.formula_weight 30573.779 _entity.pdbx_number_of_molecules 2 _entity.pdbx_ec ? _entity.pdbx_mutation ? _entity.pdbx_fragment 'residues 62-326' _entity.details ? # _entity_name_com.entity_id 1 _entity_name_com.name 'TrpV2, osm-9-like TRP channel 2, OTRPC2, Vanilloid receptor-like protein 1, VRL-1, Stretch-activated channel 2B' # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;KNTSAPSQQEPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQ IDKDSGNPKPLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTK QWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKL AAKEGKIEIFRHILQREFSGPYQPLAAAHHHHHH ; _entity_poly.pdbx_seq_one_letter_code_can ;KNTSAPSQQEPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQ IDKDSGNPKPLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTK QWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKL AAKEGKIEIFRHILQREFSGPYQPLAAAHHHHHH ; _entity_poly.pdbx_strand_id A,B _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 LYS n 1 2 ASN n 1 3 THR n 1 4 SER n 1 5 ALA n 1 6 PRO n 1 7 SER n 1 8 GLN n 1 9 GLN n 1 10 GLU n 1 11 PRO n 1 12 ASP n 1 13 ARG n 1 14 PHE n 1 15 ASP n 1 16 ARG n 1 17 ASP n 1 18 ARG n 1 19 LEU n 1 20 PHE n 1 21 SER n 1 22 VAL n 1 23 VAL n 1 24 SER n 1 25 ARG n 1 26 GLY n 1 27 VAL n 1 28 PRO n 1 29 GLU n 1 30 GLU n 1 31 LEU n 1 32 THR n 1 33 GLY n 1 34 LEU n 1 35 LEU n 1 36 GLU n 1 37 TYR n 1 38 LEU n 1 39 ARG n 1 40 TRP n 1 41 ASN n 1 42 SER n 1 43 LYS n 1 44 TYR n 1 45 LEU n 1 46 THR n 1 47 ASP n 1 48 SER n 1 49 ALA n 1 50 TYR n 1 51 THR n 1 52 GLU n 1 53 GLY n 1 54 SER n 1 55 THR n 1 56 GLY n 1 57 LYS n 1 58 THR n 1 59 CYS n 1 60 LEU n 1 61 MET n 1 62 LYS n 1 63 ALA n 1 64 VAL n 1 65 LEU n 1 66 ASN n 1 67 LEU n 1 68 GLN n 1 69 ASP n 1 70 GLY n 1 71 VAL n 1 72 ASN n 1 73 ALA n 1 74 CYS n 1 75 ILE n 1 76 MET n 1 77 PRO n 1 78 LEU n 1 79 LEU n 1 80 GLN n 1 81 ILE n 1 82 ASP n 1 83 LYS n 1 84 ASP n 1 85 SER n 1 86 GLY n 1 87 ASN n 1 88 PRO n 1 89 LYS n 1 90 PRO n 1 91 LEU n 1 92 VAL n 1 93 ASN n 1 94 ALA n 1 95 GLN n 1 96 CYS n 1 97 THR n 1 98 ASP n 1 99 GLU n 1 100 PHE n 1 101 TYR n 1 102 GLN n 1 103 GLY n 1 104 HIS n 1 105 SER n 1 106 ALA n 1 107 LEU n 1 108 HIS n 1 109 ILE n 1 110 ALA n 1 111 ILE n 1 112 GLU n 1 113 LYS n 1 114 ARG n 1 115 SER n 1 116 LEU n 1 117 GLN n 1 118 CYS n 1 119 VAL n 1 120 LYS n 1 121 LEU n 1 122 LEU n 1 123 VAL n 1 124 GLU n 1 125 ASN n 1 126 GLY n 1 127 ALA n 1 128 ASP n 1 129 VAL n 1 130 HIS n 1 131 LEU n 1 132 ARG n 1 133 ALA n 1 134 CYS n 1 135 GLY n 1 136 ARG n 1 137 PHE n 1 138 PHE n 1 139 GLN n 1 140 LYS n 1 141 HIS n 1 142 GLN n 1 143 GLY n 1 144 THR n 1 145 CYS n 1 146 PHE n 1 147 TYR n 1 148 PHE n 1 149 GLY n 1 150 GLU n 1 151 LEU n 1 152 PRO n 1 153 LEU n 1 154 SER n 1 155 LEU n 1 156 ALA n 1 157 ALA n 1 158 CYS n 1 159 THR n 1 160 LYS n 1 161 GLN n 1 162 TRP n 1 163 ASP n 1 164 VAL n 1 165 VAL n 1 166 THR n 1 167 TYR n 1 168 LEU n 1 169 LEU n 1 170 GLU n 1 171 ASN n 1 172 PRO n 1 173 HIS n 1 174 GLN n 1 175 PRO n 1 176 ALA n 1 177 SER n 1 178 LEU n 1 179 GLU n 1 180 ALA n 1 181 THR n 1 182 ASP n 1 183 SER n 1 184 LEU n 1 185 GLY n 1 186 ASN n 1 187 THR n 1 188 VAL n 1 189 LEU n 1 190 HIS n 1 191 ALA n 1 192 LEU n 1 193 VAL n 1 194 MET n 1 195 ILE n 1 196 ALA n 1 197 ASP n 1 198 ASN n 1 199 SER n 1 200 PRO n 1 201 GLU n 1 202 ASN n 1 203 SER n 1 204 ALA n 1 205 LEU n 1 206 VAL n 1 207 ILE n 1 208 HIS n 1 209 MET n 1 210 TYR n 1 211 ASP n 1 212 GLY n 1 213 LEU n 1 214 LEU n 1 215 GLN n 1 216 MET n 1 217 GLY n 1 218 ALA n 1 219 ARG n 1 220 LEU n 1 221 CYS n 1 222 PRO n 1 223 THR n 1 224 VAL n 1 225 GLN n 1 226 LEU n 1 227 GLU n 1 228 GLU n 1 229 ILE n 1 230 SER n 1 231 ASN n 1 232 HIS n 1 233 GLN n 1 234 GLY n 1 235 LEU n 1 236 THR n 1 237 PRO n 1 238 LEU n 1 239 LYS n 1 240 LEU n 1 241 ALA n 1 242 ALA n 1 243 LYS n 1 244 GLU n 1 245 GLY n 1 246 LYS n 1 247 ILE n 1 248 GLU n 1 249 ILE n 1 250 PHE n 1 251 ARG n 1 252 HIS n 1 253 ILE n 1 254 LEU n 1 255 GLN n 1 256 ARG n 1 257 GLU n 1 258 PHE n 1 259 SER n 1 260 GLY n 1 261 PRO n 1 262 TYR n 1 263 GLN n 1 264 PRO n 1 265 LEU n 1 266 ALA n 1 267 ALA n 1 268 ALA n 1 269 HIS n 1 270 HIS n 1 271 HIS n 1 272 HIS n 1 273 HIS n 1 274 HIS n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name 'Norway rat' _entity_src_gen.gene_src_genus Rattus _entity_src_gen.pdbx_gene_src_gene 'Trpv2, Sac2b, Vrl1' _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Rattus norvegicus' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 10116 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Escherichia coli BL21(DE3)' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 469008 _entity_src_gen.host_org_genus Escherichia _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species 'Escherichia coli' _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain 'BL21(DE3)' _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type PLASMID _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name pET21a _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code TRPV2_RAT _struct_ref.pdbx_db_accession Q9WUD2 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;KNTSAPSQQEPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQ IDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTK QWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKL AAKEGKIEIFRHILQREFSGPYQPL ; _struct_ref.pdbx_align_begin 62 _struct_ref.pdbx_db_isoform ? # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 2ETC A 1 ? 274 ? Q9WUD2 62 ? 326 ? 62 335 2 1 2ETC B 1 ? 274 ? Q9WUD2 62 ? 326 ? 62 335 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 2ETC PRO A 6 ? UNP Q9WUD2 LEU 151 'SEE REMARK 999' 67 1 1 2ETC ALA A 266 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 327 2 1 2ETC ALA A 267 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 328 3 1 2ETC ALA A 268 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 329 4 1 2ETC HIS A 269 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 330 5 1 2ETC HIS A 270 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 331 6 1 2ETC HIS A 271 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 332 7 1 2ETC HIS A 272 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 333 8 1 2ETC HIS A 273 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 334 9 1 2ETC HIS A 274 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 335 10 2 2ETC PRO B 6 ? UNP Q9WUD2 LEU 151 'SEE REMARK 999' 67 11 2 2ETC ALA B 266 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 327 12 2 2ETC ALA B 267 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 328 13 2 2ETC ALA B 268 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 329 14 2 2ETC HIS B 269 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 330 15 2 2ETC HIS B 270 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 331 16 2 2ETC HIS B 271 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 332 17 2 2ETC HIS B 272 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 333 18 2 2ETC HIS B 273 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 334 19 2 2ETC HIS B 274 ? UNP Q9WUD2 ? ? 'CLONING ARTIFACT' 335 20 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 2ETC _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 2.64 _exptl_crystal.density_percent_sol 53.34 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 277 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 5.0 _exptl_crystal_grow.pdbx_details '0.33mM protein, 9% PEG8000, 0.1M sodium citrate, pH 5.0, 5-7% xylitol, VAPOR DIFFUSION, HANGING DROP, temperature 277K' _exptl_crystal_grow.pdbx_pH_range . # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'ADSC QUANTUM 4' _diffrn_detector.pdbx_collection_date 2004-06-04 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.97922 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'APS BEAMLINE 8-BM' _diffrn_source.pdbx_synchrotron_site APS _diffrn_source.pdbx_synchrotron_beamline 8-BM _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 0.97922 # _reflns.entry_id 2ETC _reflns.observed_criterion_sigma_I 1.0 _reflns.observed_criterion_sigma_F 1.0 _reflns.d_resolution_low 48.0 _reflns.d_resolution_high 3.1 _reflns.number_obs 11944 _reflns.number_all 11981 _reflns.percent_possible_obs 99.7 _reflns.pdbx_Rmerge_I_obs 0.14 _reflns.pdbx_Rsym_value 0.1 _reflns.pdbx_netI_over_sigmaI 17.4 _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 6.7 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 # _reflns_shell.d_res_high 3.1 _reflns_shell.d_res_low 3.21 _reflns_shell.percent_possible_all 100 _reflns_shell.Rmerge_I_obs 0.493 _reflns_shell.pdbx_Rsym_value 0.447 _reflns_shell.meanI_over_sigI_obs 5.3 _reflns_shell.pdbx_redundancy 7.1 _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all ? _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_diffrn_id ? _reflns_shell.pdbx_ordinal 1 # _refine.entry_id 2ETC _refine.ls_number_reflns_obs 10738 _refine.ls_number_reflns_all 11944 _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 0 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 20.00 _refine.ls_d_res_high 3.10 _refine.ls_percent_reflns_obs 99.89 _refine.ls_R_factor_obs 0.21499 _refine.ls_R_factor_all 0.307 _refine.ls_R_factor_R_work 0.20979 _refine.ls_R_factor_R_free 0.26184 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 9.8 _refine.ls_number_reflns_R_free 1170 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.924 _refine.correlation_coeff_Fo_to_Fc_free 0.873 _refine.B_iso_mean 40.874 _refine.aniso_B[1][1] 2.57 _refine.aniso_B[2][2] -1.10 _refine.aniso_B[3][3] -1.47 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details MASK _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.20 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details ? _refine.pdbx_starting_model 'PDB ENTRY 2ETA' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free 0.507 _refine.overall_SU_ML 0.357 _refine.overall_SU_B 45.800 _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_phase_error ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 3896 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 0 _refine_hist.number_atoms_solvent 0 _refine_hist.number_atoms_total 3896 _refine_hist.d_res_high 3.10 _refine_hist.d_res_low 20.00 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.006 0.022 ? 3972 'X-RAY DIFFRACTION' ? r_bond_other_d ? ? ? ? 'X-RAY DIFFRACTION' ? r_angle_refined_deg 0.961 1.970 ? 5385 'X-RAY DIFFRACTION' ? r_angle_other_deg ? ? ? ? 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 4.757 5.000 ? 497 'X-RAY DIFFRACTION' ? r_dihedral_angle_2_deg 40.493 24.780 ? 182 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 16.859 15.000 ? 690 'X-RAY DIFFRACTION' ? r_dihedral_angle_4_deg 15.056 15.000 ? 22 'X-RAY DIFFRACTION' ? r_chiral_restr 0.064 0.200 ? 614 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.002 0.020 ? 2988 'X-RAY DIFFRACTION' ? r_gen_planes_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_refined 0.191 0.200 ? 1800 'X-RAY DIFFRACTION' ? r_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_refined 0.293 0.200 ? 2740 'X-RAY DIFFRACTION' ? r_nbtor_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined 0.096 0.200 ? 101 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined 0.152 0.200 ? 47 'X-RAY DIFFRACTION' ? r_symmetry_vdw_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined 0.237 0.200 ? 2 'X-RAY DIFFRACTION' ? r_symmetry_hbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcbond_it 0.174 1.500 ? 2544 'X-RAY DIFFRACTION' ? r_mcbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcangle_it 0.323 2.000 ? 3997 'X-RAY DIFFRACTION' ? r_scbond_it 0.371 3.000 ? 1577 'X-RAY DIFFRACTION' ? r_scangle_it 0.646 4.500 ? 1388 'X-RAY DIFFRACTION' ? r_rigid_bond_restr ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_free ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_bonded ? ? ? ? 'X-RAY DIFFRACTION' ? # loop_ _refine_ls_restr_ncs.dom_id _refine_ls_restr_ncs.pdbx_auth_asym_id _refine_ls_restr_ncs.pdbx_number _refine_ls_restr_ncs.rms_dev_position _refine_ls_restr_ncs.weight_position _refine_ls_restr_ncs.pdbx_type _refine_ls_restr_ncs.pdbx_ens_id _refine_ls_restr_ncs.pdbx_refine_id _refine_ls_restr_ncs.pdbx_ordinal _refine_ls_restr_ncs.ncs_model_details _refine_ls_restr_ncs.rms_dev_B_iso _refine_ls_restr_ncs.weight_B_iso 1 A 1901 0.38 0.50 'medium positional' 1 'X-RAY DIFFRACTION' 1 ? ? ? 1 A 1901 0.13 2.00 'medium thermal' 1 'X-RAY DIFFRACTION' 2 ? ? ? # _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 3.102 _refine_ls_shell.d_res_low 3.181 _refine_ls_shell.number_reflns_R_work 767 _refine_ls_shell.R_factor_R_work 0.285 _refine_ls_shell.percent_reflns_obs 99.05 _refine_ls_shell.R_factor_R_free 0.348 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 71 _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' # loop_ _struct_ncs_dom.pdbx_ens_id _struct_ncs_dom.id _struct_ncs_dom.details 1 1 A 1 2 B # loop_ _struct_ncs_dom_lim.dom_id _struct_ncs_dom_lim.beg_auth_asym_id _struct_ncs_dom_lim.beg_auth_seq_id _struct_ncs_dom_lim.end_auth_asym_id _struct_ncs_dom_lim.end_auth_seq_id _struct_ncs_dom_lim.pdbx_component_id _struct_ncs_dom_lim.pdbx_refine_code _struct_ncs_dom_lim.beg_label_asym_id _struct_ncs_dom_lim.beg_label_comp_id _struct_ncs_dom_lim.beg_label_seq_id _struct_ncs_dom_lim.beg_label_alt_id _struct_ncs_dom_lim.end_label_asym_id _struct_ncs_dom_lim.end_label_comp_id _struct_ncs_dom_lim.end_label_seq_id _struct_ncs_dom_lim.end_label_alt_id _struct_ncs_dom_lim.pdbx_ens_id _struct_ncs_dom_lim.selection_details 1 A 70 A 319 1 4 A GLN 9 ? A PHE 258 ? 1 ? 2 B 70 B 319 1 4 B GLN 9 ? B PHE 258 ? 1 ? # _struct_ncs_ens.id 1 _struct_ncs_ens.details ? # _struct.entry_id 2ETC _struct.title 'Crystal structure of the ankyrin repeat domain of TRPV2' _struct.pdbx_descriptor 'Transient receptor potential cation channel subfamily V member 2' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 2ETC _struct_keywords.pdbx_keywords 'TRANSPORT PROTEIN' _struct_keywords.text 'TRPV2, ankyrin repeat domain, TRANSPORT PROTEIN' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 1 ? # loop_ _struct_biol.id _struct_biol.details _struct_biol.pdbx_parent_biol_id 1 'The biological assembly is a monomer in the asymmetric unit.' ? 2 ? ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 ASP A 15 ? GLY A 26 ? ASP A 76 GLY A 87 1 ? 12 HELX_P HELX_P2 2 VAL A 27 ? THR A 32 ? VAL A 88 THR A 93 5 ? 6 HELX_P HELX_P3 3 GLY A 33 ? ASN A 41 ? GLY A 94 ASN A 102 1 ? 9 HELX_P HELX_P4 4 ASP A 47 ? THR A 51 ? ASP A 108 THR A 112 5 ? 5 HELX_P HELX_P5 5 THR A 58 ? ASN A 66 ? THR A 119 ASN A 127 1 ? 9 HELX_P HELX_P6 6 CYS A 74 ? SER A 85 ? CYS A 135 SER A 146 1 ? 12 HELX_P HELX_P7 7 PRO A 90 ? ASN A 93 ? PRO A 151 ASN A 154 5 ? 4 HELX_P HELX_P8 8 ALA A 106 ? LYS A 113 ? ALA A 167 LYS A 174 1 ? 8 HELX_P HELX_P9 9 SER A 115 ? GLU A 124 ? SER A 176 GLU A 185 1 ? 10 HELX_P HELX_P10 10 LEU A 151 ? THR A 159 ? LEU A 212 THR A 220 1 ? 9 HELX_P HELX_P11 11 GLN A 161 ? ASN A 171 ? GLN A 222 ASN A 232 1 ? 11 HELX_P HELX_P12 12 THR A 187 ? ALA A 196 ? THR A 248 ALA A 257 1 ? 10 HELX_P HELX_P13 13 SER A 199 ? CYS A 221 ? SER A 260 CYS A 282 1 ? 23 HELX_P HELX_P14 14 GLN A 225 ? ILE A 229 ? GLN A 286 ILE A 290 5 ? 5 HELX_P HELX_P15 15 THR A 236 ? GLU A 244 ? THR A 297 GLU A 305 1 ? 9 HELX_P HELX_P16 16 LYS A 246 ? PHE A 258 ? LYS A 307 PHE A 319 1 ? 13 HELX_P HELX_P17 17 ASP B 15 ? ARG B 25 ? ASP B 76 ARG B 86 1 ? 11 HELX_P HELX_P18 18 VAL B 27 ? THR B 32 ? VAL B 88 THR B 93 5 ? 6 HELX_P HELX_P19 19 GLY B 33 ? ASN B 41 ? GLY B 94 ASN B 102 1 ? 9 HELX_P HELX_P20 20 ASP B 47 ? THR B 51 ? ASP B 108 THR B 112 5 ? 5 HELX_P HELX_P21 21 THR B 58 ? ASN B 66 ? THR B 119 ASN B 127 1 ? 9 HELX_P HELX_P22 22 CYS B 74 ? SER B 85 ? CYS B 135 SER B 146 1 ? 12 HELX_P HELX_P23 23 PRO B 90 ? ASN B 93 ? PRO B 151 ASN B 154 5 ? 4 HELX_P HELX_P24 24 ALA B 106 ? LYS B 113 ? ALA B 167 LYS B 174 1 ? 8 HELX_P HELX_P25 25 SER B 115 ? GLU B 124 ? SER B 176 GLU B 185 1 ? 10 HELX_P HELX_P26 26 LEU B 151 ? THR B 159 ? LEU B 212 THR B 220 1 ? 9 HELX_P HELX_P27 27 GLN B 161 ? ASN B 171 ? GLN B 222 ASN B 232 1 ? 11 HELX_P HELX_P28 28 THR B 187 ? ALA B 196 ? THR B 248 ALA B 257 1 ? 10 HELX_P HELX_P29 29 SER B 199 ? CYS B 221 ? SER B 260 CYS B 282 1 ? 23 HELX_P HELX_P30 30 GLN B 225 ? ILE B 229 ? GLN B 286 ILE B 290 5 ? 5 HELX_P HELX_P31 31 THR B 236 ? GLU B 244 ? THR B 297 GLU B 305 1 ? 9 HELX_P HELX_P32 32 LYS B 246 ? ARG B 256 ? LYS B 307 ARG B 317 1 ? 11 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 134 SG ? ? ? 1_555 A CYS 145 SG ? ? A CYS 195 A CYS 206 1_555 ? ? ? ? ? ? ? 2.052 ? disulf2 disulf ? ? B CYS 134 SG ? ? ? 1_555 B CYS 145 SG ? ? B CYS 195 B CYS 206 1_555 ? ? ? ? ? ? ? 2.043 ? # _struct_conn_type.id disulf _struct_conn_type.criteria ? _struct_conn_type.reference ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 GLU 10 A . ? GLU 71 A PRO 11 A ? PRO 72 A 1 -18.66 2 GLN 9 B . ? GLN 70 B GLU 10 B ? GLU 71 B 1 1.91 3 GLU 10 B . ? GLU 71 B PRO 11 B ? PRO 72 B 1 -1.91 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 2 ? B ? 2 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? anti-parallel B 1 2 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 GLN A 95 ? CYS A 96 ? GLN A 156 CYS A 157 A 2 HIS A 104 ? SER A 105 ? HIS A 165 SER A 166 B 1 GLN B 95 ? THR B 97 ? GLN B 156 THR B 158 B 2 GLN B 102 ? SER B 105 ? GLN B 163 SER B 166 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 N CYS A 96 ? N CYS A 157 O HIS A 104 ? O HIS A 165 B 1 2 N CYS B 96 ? N CYS B 157 O HIS B 104 ? O HIS B 165 # _database_PDB_matrix.entry_id 2ETC _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 2ETC _atom_sites.fract_transf_matrix[1][1] 0.025307 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.010432 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.006079 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 LYS 1 62 ? ? ? A . n A 1 2 ASN 2 63 ? ? ? A . n A 1 3 THR 3 64 ? ? ? A . n A 1 4 SER 4 65 ? ? ? A . n A 1 5 ALA 5 66 ? ? ? A . n A 1 6 PRO 6 67 ? ? ? A . n A 1 7 SER 7 68 ? ? ? A . n A 1 8 GLN 8 69 69 GLN GLN A . n A 1 9 GLN 9 70 70 GLN GLN A . n A 1 10 GLU 10 71 71 GLU GLU A . n A 1 11 PRO 11 72 72 PRO PRO A . n A 1 12 ASP 12 73 73 ASP ASP A . n A 1 13 ARG 13 74 74 ARG ARG A . n A 1 14 PHE 14 75 75 PHE PHE A . n A 1 15 ASP 15 76 76 ASP ASP A . n A 1 16 ARG 16 77 77 ARG ARG A . n A 1 17 ASP 17 78 78 ASP ASP A . n A 1 18 ARG 18 79 79 ARG ARG A . n A 1 19 LEU 19 80 80 LEU LEU A . n A 1 20 PHE 20 81 81 PHE PHE A . n A 1 21 SER 21 82 82 SER SER A . n A 1 22 VAL 22 83 83 VAL VAL A . n A 1 23 VAL 23 84 84 VAL VAL A . n A 1 24 SER 24 85 85 SER SER A . n A 1 25 ARG 25 86 86 ARG ARG A . n A 1 26 GLY 26 87 87 GLY GLY A . n A 1 27 VAL 27 88 88 VAL VAL A . n A 1 28 PRO 28 89 89 PRO PRO A . n A 1 29 GLU 29 90 90 GLU GLU A . n A 1 30 GLU 30 91 91 GLU GLU A . n A 1 31 LEU 31 92 92 LEU LEU A . n A 1 32 THR 32 93 93 THR THR A . n A 1 33 GLY 33 94 94 GLY GLY A . n A 1 34 LEU 34 95 95 LEU LEU A . n A 1 35 LEU 35 96 96 LEU LEU A . n A 1 36 GLU 36 97 97 GLU GLU A . n A 1 37 TYR 37 98 98 TYR TYR A . n A 1 38 LEU 38 99 99 LEU LEU A . n A 1 39 ARG 39 100 100 ARG ARG A . n A 1 40 TRP 40 101 101 TRP TRP A . n A 1 41 ASN 41 102 102 ASN ASN A . n A 1 42 SER 42 103 103 SER SER A . n A 1 43 LYS 43 104 104 LYS LYS A . n A 1 44 TYR 44 105 105 TYR TYR A . n A 1 45 LEU 45 106 106 LEU LEU A . n A 1 46 THR 46 107 107 THR THR A . n A 1 47 ASP 47 108 108 ASP ASP A . n A 1 48 SER 48 109 109 SER SER A . n A 1 49 ALA 49 110 110 ALA ALA A . n A 1 50 TYR 50 111 111 TYR TYR A . n A 1 51 THR 51 112 112 THR THR A . n A 1 52 GLU 52 113 113 GLU GLU A . n A 1 53 GLY 53 114 114 GLY GLY A . n A 1 54 SER 54 115 115 SER SER A . n A 1 55 THR 55 116 116 THR THR A . n A 1 56 GLY 56 117 117 GLY GLY A . n A 1 57 LYS 57 118 118 LYS LYS A . n A 1 58 THR 58 119 119 THR THR A . n A 1 59 CYS 59 120 120 CYS CYS A . n A 1 60 LEU 60 121 121 LEU LEU A . n A 1 61 MET 61 122 122 MET MET A . n A 1 62 LYS 62 123 123 LYS LYS A . n A 1 63 ALA 63 124 124 ALA ALA A . n A 1 64 VAL 64 125 125 VAL VAL A . n A 1 65 LEU 65 126 126 LEU LEU A . n A 1 66 ASN 66 127 127 ASN ASN A . n A 1 67 LEU 67 128 128 LEU LEU A . n A 1 68 GLN 68 129 129 GLN GLN A . n A 1 69 ASP 69 130 130 ASP ASP A . n A 1 70 GLY 70 131 131 GLY GLY A . n A 1 71 VAL 71 132 132 VAL VAL A . n A 1 72 ASN 72 133 133 ASN ASN A . n A 1 73 ALA 73 134 134 ALA ALA A . n A 1 74 CYS 74 135 135 CYS CYS A . n A 1 75 ILE 75 136 136 ILE ILE A . n A 1 76 MET 76 137 137 MET MET A . n A 1 77 PRO 77 138 138 PRO PRO A . n A 1 78 LEU 78 139 139 LEU LEU A . n A 1 79 LEU 79 140 140 LEU LEU A . n A 1 80 GLN 80 141 141 GLN GLN A . n A 1 81 ILE 81 142 142 ILE ILE A . n A 1 82 ASP 82 143 143 ASP ASP A . n A 1 83 LYS 83 144 144 LYS LYS A . n A 1 84 ASP 84 145 145 ASP ASP A . n A 1 85 SER 85 146 146 SER SER A . n A 1 86 GLY 86 147 147 GLY GLY A . n A 1 87 ASN 87 148 148 ASN ASN A . n A 1 88 PRO 88 149 149 PRO PRO A . n A 1 89 LYS 89 150 150 LYS LYS A . n A 1 90 PRO 90 151 151 PRO PRO A . n A 1 91 LEU 91 152 152 LEU LEU A . n A 1 92 VAL 92 153 153 VAL VAL A . n A 1 93 ASN 93 154 154 ASN ASN A . n A 1 94 ALA 94 155 155 ALA ALA A . n A 1 95 GLN 95 156 156 GLN GLN A . n A 1 96 CYS 96 157 157 CYS CYS A . n A 1 97 THR 97 158 158 THR THR A . n A 1 98 ASP 98 159 159 ASP ASP A . n A 1 99 GLU 99 160 160 GLU GLU A . n A 1 100 PHE 100 161 161 PHE PHE A . n A 1 101 TYR 101 162 162 TYR TYR A . n A 1 102 GLN 102 163 163 GLN GLN A . n A 1 103 GLY 103 164 164 GLY GLY A . n A 1 104 HIS 104 165 165 HIS HIS A . n A 1 105 SER 105 166 166 SER SER A . n A 1 106 ALA 106 167 167 ALA ALA A . n A 1 107 LEU 107 168 168 LEU LEU A . n A 1 108 HIS 108 169 169 HIS HIS A . n A 1 109 ILE 109 170 170 ILE ILE A . n A 1 110 ALA 110 171 171 ALA ALA A . n A 1 111 ILE 111 172 172 ILE ILE A . n A 1 112 GLU 112 173 173 GLU GLU A . n A 1 113 LYS 113 174 174 LYS LYS A . n A 1 114 ARG 114 175 175 ARG ARG A . n A 1 115 SER 115 176 176 SER SER A . n A 1 116 LEU 116 177 177 LEU LEU A . n A 1 117 GLN 117 178 178 GLN GLN A . n A 1 118 CYS 118 179 179 CYS CYS A . n A 1 119 VAL 119 180 180 VAL VAL A . n A 1 120 LYS 120 181 181 LYS LYS A . n A 1 121 LEU 121 182 182 LEU LEU A . n A 1 122 LEU 122 183 183 LEU LEU A . n A 1 123 VAL 123 184 184 VAL VAL A . n A 1 124 GLU 124 185 185 GLU GLU A . n A 1 125 ASN 125 186 186 ASN ASN A . n A 1 126 GLY 126 187 187 GLY GLY A . n A 1 127 ALA 127 188 188 ALA ALA A . n A 1 128 ASP 128 189 189 ASP ASP A . n A 1 129 VAL 129 190 190 VAL VAL A . n A 1 130 HIS 130 191 191 HIS HIS A . n A 1 131 LEU 131 192 192 LEU LEU A . n A 1 132 ARG 132 193 193 ARG ARG A . n A 1 133 ALA 133 194 194 ALA ALA A . n A 1 134 CYS 134 195 195 CYS CYS A . n A 1 135 GLY 135 196 196 GLY GLY A . n A 1 136 ARG 136 197 197 ARG ARG A . n A 1 137 PHE 137 198 198 PHE PHE A . n A 1 138 PHE 138 199 199 PHE PHE A . n A 1 139 GLN 139 200 200 GLN GLN A . n A 1 140 LYS 140 201 201 LYS LYS A . n A 1 141 HIS 141 202 202 HIS HIS A . n A 1 142 GLN 142 203 203 GLN GLN A . n A 1 143 GLY 143 204 204 GLY GLY A . n A 1 144 THR 144 205 205 THR THR A . n A 1 145 CYS 145 206 206 CYS CYS A . n A 1 146 PHE 146 207 207 PHE PHE A . n A 1 147 TYR 147 208 208 TYR TYR A . n A 1 148 PHE 148 209 209 PHE PHE A . n A 1 149 GLY 149 210 210 GLY GLY A . n A 1 150 GLU 150 211 211 GLU GLU A . n A 1 151 LEU 151 212 212 LEU LEU A . n A 1 152 PRO 152 213 213 PRO PRO A . n A 1 153 LEU 153 214 214 LEU LEU A . n A 1 154 SER 154 215 215 SER SER A . n A 1 155 LEU 155 216 216 LEU LEU A . n A 1 156 ALA 156 217 217 ALA ALA A . n A 1 157 ALA 157 218 218 ALA ALA A . n A 1 158 CYS 158 219 219 CYS CYS A . n A 1 159 THR 159 220 220 THR THR A . n A 1 160 LYS 160 221 221 LYS LYS A . n A 1 161 GLN 161 222 222 GLN GLN A . n A 1 162 TRP 162 223 223 TRP TRP A . n A 1 163 ASP 163 224 224 ASP ASP A . n A 1 164 VAL 164 225 225 VAL VAL A . n A 1 165 VAL 165 226 226 VAL VAL A . n A 1 166 THR 166 227 227 THR THR A . n A 1 167 TYR 167 228 228 TYR TYR A . n A 1 168 LEU 168 229 229 LEU LEU A . n A 1 169 LEU 169 230 230 LEU LEU A . n A 1 170 GLU 170 231 231 GLU GLU A . n A 1 171 ASN 171 232 232 ASN ASN A . n A 1 172 PRO 172 233 233 PRO PRO A . n A 1 173 HIS 173 234 234 HIS HIS A . n A 1 174 GLN 174 235 235 GLN GLN A . n A 1 175 PRO 175 236 236 PRO PRO A . n A 1 176 ALA 176 237 237 ALA ALA A . n A 1 177 SER 177 238 238 SER SER A . n A 1 178 LEU 178 239 239 LEU LEU A . n A 1 179 GLU 179 240 240 GLU GLU A . n A 1 180 ALA 180 241 241 ALA ALA A . n A 1 181 THR 181 242 242 THR THR A . n A 1 182 ASP 182 243 243 ASP ASP A . n A 1 183 SER 183 244 244 SER SER A . n A 1 184 LEU 184 245 245 LEU LEU A . n A 1 185 GLY 185 246 246 GLY GLY A . n A 1 186 ASN 186 247 247 ASN ASN A . n A 1 187 THR 187 248 248 THR THR A . n A 1 188 VAL 188 249 249 VAL VAL A . n A 1 189 LEU 189 250 250 LEU LEU A . n A 1 190 HIS 190 251 251 HIS HIS A . n A 1 191 ALA 191 252 252 ALA ALA A . n A 1 192 LEU 192 253 253 LEU LEU A . n A 1 193 VAL 193 254 254 VAL VAL A . n A 1 194 MET 194 255 255 MET MET A . n A 1 195 ILE 195 256 256 ILE ILE A . n A 1 196 ALA 196 257 257 ALA ALA A . n A 1 197 ASP 197 258 258 ASP ASP A . n A 1 198 ASN 198 259 259 ASN ASN A . n A 1 199 SER 199 260 260 SER SER A . n A 1 200 PRO 200 261 261 PRO PRO A . n A 1 201 GLU 201 262 262 GLU GLU A . n A 1 202 ASN 202 263 263 ASN ASN A . n A 1 203 SER 203 264 264 SER SER A . n A 1 204 ALA 204 265 265 ALA ALA A . n A 1 205 LEU 205 266 266 LEU LEU A . n A 1 206 VAL 206 267 267 VAL VAL A . n A 1 207 ILE 207 268 268 ILE ILE A . n A 1 208 HIS 208 269 269 HIS HIS A . n A 1 209 MET 209 270 270 MET MET A . n A 1 210 TYR 210 271 271 TYR TYR A . n A 1 211 ASP 211 272 272 ASP ASP A . n A 1 212 GLY 212 273 273 GLY GLY A . n A 1 213 LEU 213 274 274 LEU LEU A . n A 1 214 LEU 214 275 275 LEU LEU A . n A 1 215 GLN 215 276 276 GLN GLN A . n A 1 216 MET 216 277 277 MET MET A . n A 1 217 GLY 217 278 278 GLY GLY A . n A 1 218 ALA 218 279 279 ALA ALA A . n A 1 219 ARG 219 280 280 ARG ARG A . n A 1 220 LEU 220 281 281 LEU LEU A . n A 1 221 CYS 221 282 282 CYS CYS A . n A 1 222 PRO 222 283 283 PRO PRO A . n A 1 223 THR 223 284 284 THR THR A . n A 1 224 VAL 224 285 285 VAL VAL A . n A 1 225 GLN 225 286 286 GLN GLN A . n A 1 226 LEU 226 287 287 LEU LEU A . n A 1 227 GLU 227 288 288 GLU GLU A . n A 1 228 GLU 228 289 289 GLU GLU A . n A 1 229 ILE 229 290 290 ILE ILE A . n A 1 230 SER 230 291 291 SER SER A . n A 1 231 ASN 231 292 292 ASN ASN A . n A 1 232 HIS 232 293 293 HIS HIS A . n A 1 233 GLN 233 294 294 GLN GLN A . n A 1 234 GLY 234 295 295 GLY GLY A . n A 1 235 LEU 235 296 296 LEU LEU A . n A 1 236 THR 236 297 297 THR THR A . n A 1 237 PRO 237 298 298 PRO PRO A . n A 1 238 LEU 238 299 299 LEU LEU A . n A 1 239 LYS 239 300 300 LYS LYS A . n A 1 240 LEU 240 301 301 LEU LEU A . n A 1 241 ALA 241 302 302 ALA ALA A . n A 1 242 ALA 242 303 303 ALA ALA A . n A 1 243 LYS 243 304 304 LYS LYS A . n A 1 244 GLU 244 305 305 GLU GLU A . n A 1 245 GLY 245 306 306 GLY GLY A . n A 1 246 LYS 246 307 307 LYS LYS A . n A 1 247 ILE 247 308 308 ILE ILE A . n A 1 248 GLU 248 309 309 GLU GLU A . n A 1 249 ILE 249 310 310 ILE ILE A . n A 1 250 PHE 250 311 311 PHE PHE A . n A 1 251 ARG 251 312 312 ARG ARG A . n A 1 252 HIS 252 313 313 HIS HIS A . n A 1 253 ILE 253 314 314 ILE ILE A . n A 1 254 LEU 254 315 315 LEU LEU A . n A 1 255 GLN 255 316 316 GLN GLN A . n A 1 256 ARG 256 317 317 ARG ARG A . n A 1 257 GLU 257 318 318 GLU GLU A . n A 1 258 PHE 258 319 319 PHE PHE A . n A 1 259 SER 259 320 320 SER SER A . n A 1 260 GLY 260 321 ? ? ? A . n A 1 261 PRO 261 322 ? ? ? A . n A 1 262 TYR 262 323 ? ? ? A . n A 1 263 GLN 263 324 ? ? ? A . n A 1 264 PRO 264 325 ? ? ? A . n A 1 265 LEU 265 326 ? ? ? A . n A 1 266 ALA 266 327 ? ? ? A . n A 1 267 ALA 267 328 ? ? ? A . n A 1 268 ALA 268 329 ? ? ? A . n A 1 269 HIS 269 330 ? ? ? A . n A 1 270 HIS 270 331 ? ? ? A . n A 1 271 HIS 271 332 ? ? ? A . n A 1 272 HIS 272 333 ? ? ? A . n A 1 273 HIS 273 334 ? ? ? A . n A 1 274 HIS 274 335 ? ? ? A . n B 1 1 LYS 1 62 ? ? ? B . n B 1 2 ASN 2 63 ? ? ? B . n B 1 3 THR 3 64 ? ? ? B . n B 1 4 SER 4 65 ? ? ? B . n B 1 5 ALA 5 66 ? ? ? B . n B 1 6 PRO 6 67 ? ? ? B . n B 1 7 SER 7 68 ? ? ? B . n B 1 8 GLN 8 69 ? ? ? B . n B 1 9 GLN 9 70 70 GLN GLN B . n B 1 10 GLU 10 71 71 GLU GLU B . n B 1 11 PRO 11 72 72 PRO PRO B . n B 1 12 ASP 12 73 73 ASP ASP B . n B 1 13 ARG 13 74 74 ARG ARG B . n B 1 14 PHE 14 75 75 PHE PHE B . n B 1 15 ASP 15 76 76 ASP ASP B . n B 1 16 ARG 16 77 77 ARG ARG B . n B 1 17 ASP 17 78 78 ASP ASP B . n B 1 18 ARG 18 79 79 ARG ARG B . n B 1 19 LEU 19 80 80 LEU LEU B . n B 1 20 PHE 20 81 81 PHE PHE B . n B 1 21 SER 21 82 82 SER SER B . n B 1 22 VAL 22 83 83 VAL VAL B . n B 1 23 VAL 23 84 84 VAL VAL B . n B 1 24 SER 24 85 85 SER SER B . n B 1 25 ARG 25 86 86 ARG ARG B . n B 1 26 GLY 26 87 87 GLY GLY B . n B 1 27 VAL 27 88 88 VAL VAL B . n B 1 28 PRO 28 89 89 PRO PRO B . n B 1 29 GLU 29 90 90 GLU GLU B . n B 1 30 GLU 30 91 91 GLU GLU B . n B 1 31 LEU 31 92 92 LEU LEU B . n B 1 32 THR 32 93 93 THR THR B . n B 1 33 GLY 33 94 94 GLY GLY B . n B 1 34 LEU 34 95 95 LEU LEU B . n B 1 35 LEU 35 96 96 LEU LEU B . n B 1 36 GLU 36 97 97 GLU GLU B . n B 1 37 TYR 37 98 98 TYR TYR B . n B 1 38 LEU 38 99 99 LEU LEU B . n B 1 39 ARG 39 100 100 ARG ARG B . n B 1 40 TRP 40 101 101 TRP TRP B . n B 1 41 ASN 41 102 102 ASN ASN B . n B 1 42 SER 42 103 103 SER SER B . n B 1 43 LYS 43 104 104 LYS LYS B . n B 1 44 TYR 44 105 105 TYR TYR B . n B 1 45 LEU 45 106 106 LEU LEU B . n B 1 46 THR 46 107 107 THR THR B . n B 1 47 ASP 47 108 108 ASP ASP B . n B 1 48 SER 48 109 109 SER SER B . n B 1 49 ALA 49 110 110 ALA ALA B . n B 1 50 TYR 50 111 111 TYR TYR B . n B 1 51 THR 51 112 112 THR THR B . n B 1 52 GLU 52 113 113 GLU GLU B . n B 1 53 GLY 53 114 114 GLY GLY B . n B 1 54 SER 54 115 115 SER SER B . n B 1 55 THR 55 116 116 THR THR B . n B 1 56 GLY 56 117 117 GLY GLY B . n B 1 57 LYS 57 118 118 LYS LYS B . n B 1 58 THR 58 119 119 THR THR B . n B 1 59 CYS 59 120 120 CYS CYS B . n B 1 60 LEU 60 121 121 LEU LEU B . n B 1 61 MET 61 122 122 MET MET B . n B 1 62 LYS 62 123 123 LYS LYS B . n B 1 63 ALA 63 124 124 ALA ALA B . n B 1 64 VAL 64 125 125 VAL VAL B . n B 1 65 LEU 65 126 126 LEU LEU B . n B 1 66 ASN 66 127 127 ASN ASN B . n B 1 67 LEU 67 128 128 LEU LEU B . n B 1 68 GLN 68 129 129 GLN GLN B . n B 1 69 ASP 69 130 130 ASP ASP B . n B 1 70 GLY 70 131 131 GLY GLY B . n B 1 71 VAL 71 132 132 VAL VAL B . n B 1 72 ASN 72 133 133 ASN ASN B . n B 1 73 ALA 73 134 134 ALA ALA B . n B 1 74 CYS 74 135 135 CYS CYS B . n B 1 75 ILE 75 136 136 ILE ILE B . n B 1 76 MET 76 137 137 MET MET B . n B 1 77 PRO 77 138 138 PRO PRO B . n B 1 78 LEU 78 139 139 LEU LEU B . n B 1 79 LEU 79 140 140 LEU LEU B . n B 1 80 GLN 80 141 141 GLN GLN B . n B 1 81 ILE 81 142 142 ILE ILE B . n B 1 82 ASP 82 143 143 ASP ASP B . n B 1 83 LYS 83 144 144 LYS LYS B . n B 1 84 ASP 84 145 145 ASP ASP B . n B 1 85 SER 85 146 146 SER SER B . n B 1 86 GLY 86 147 147 GLY GLY B . n B 1 87 ASN 87 148 148 ASN ASN B . n B 1 88 PRO 88 149 149 PRO PRO B . n B 1 89 LYS 89 150 150 LYS LYS B . n B 1 90 PRO 90 151 151 PRO PRO B . n B 1 91 LEU 91 152 152 LEU LEU B . n B 1 92 VAL 92 153 153 VAL VAL B . n B 1 93 ASN 93 154 154 ASN ASN B . n B 1 94 ALA 94 155 155 ALA ALA B . n B 1 95 GLN 95 156 156 GLN GLN B . n B 1 96 CYS 96 157 157 CYS CYS B . n B 1 97 THR 97 158 158 THR THR B . n B 1 98 ASP 98 159 159 ASP ASP B . n B 1 99 GLU 99 160 160 GLU GLU B . n B 1 100 PHE 100 161 161 PHE PHE B . n B 1 101 TYR 101 162 162 TYR TYR B . n B 1 102 GLN 102 163 163 GLN GLN B . n B 1 103 GLY 103 164 164 GLY GLY B . n B 1 104 HIS 104 165 165 HIS HIS B . n B 1 105 SER 105 166 166 SER SER B . n B 1 106 ALA 106 167 167 ALA ALA B . n B 1 107 LEU 107 168 168 LEU LEU B . n B 1 108 HIS 108 169 169 HIS HIS B . n B 1 109 ILE 109 170 170 ILE ILE B . n B 1 110 ALA 110 171 171 ALA ALA B . n B 1 111 ILE 111 172 172 ILE ILE B . n B 1 112 GLU 112 173 173 GLU GLU B . n B 1 113 LYS 113 174 174 LYS LYS B . n B 1 114 ARG 114 175 175 ARG ARG B . n B 1 115 SER 115 176 176 SER SER B . n B 1 116 LEU 116 177 177 LEU LEU B . n B 1 117 GLN 117 178 178 GLN GLN B . n B 1 118 CYS 118 179 179 CYS CYS B . n B 1 119 VAL 119 180 180 VAL VAL B . n B 1 120 LYS 120 181 181 LYS LYS B . n B 1 121 LEU 121 182 182 LEU LEU B . n B 1 122 LEU 122 183 183 LEU LEU B . n B 1 123 VAL 123 184 184 VAL VAL B . n B 1 124 GLU 124 185 185 GLU GLU B . n B 1 125 ASN 125 186 186 ASN ASN B . n B 1 126 GLY 126 187 187 GLY GLY B . n B 1 127 ALA 127 188 188 ALA ALA B . n B 1 128 ASP 128 189 189 ASP ASP B . n B 1 129 VAL 129 190 190 VAL VAL B . n B 1 130 HIS 130 191 191 HIS HIS B . n B 1 131 LEU 131 192 192 LEU LEU B . n B 1 132 ARG 132 193 193 ARG ARG B . n B 1 133 ALA 133 194 194 ALA ALA B . n B 1 134 CYS 134 195 195 CYS CYS B . n B 1 135 GLY 135 196 196 GLY GLY B . n B 1 136 ARG 136 197 197 ARG ARG B . n B 1 137 PHE 137 198 198 PHE PHE B . n B 1 138 PHE 138 199 199 PHE PHE B . n B 1 139 GLN 139 200 200 GLN GLN B . n B 1 140 LYS 140 201 201 LYS LYS B . n B 1 141 HIS 141 202 ? ? ? B . n B 1 142 GLN 142 203 ? ? ? B . n B 1 143 GLY 143 204 204 GLY GLY B . n B 1 144 THR 144 205 205 THR THR B . n B 1 145 CYS 145 206 206 CYS CYS B . n B 1 146 PHE 146 207 207 PHE PHE B . n B 1 147 TYR 147 208 208 TYR TYR B . n B 1 148 PHE 148 209 209 PHE PHE B . n B 1 149 GLY 149 210 210 GLY GLY B . n B 1 150 GLU 150 211 211 GLU GLU B . n B 1 151 LEU 151 212 212 LEU LEU B . n B 1 152 PRO 152 213 213 PRO PRO B . n B 1 153 LEU 153 214 214 LEU LEU B . n B 1 154 SER 154 215 215 SER SER B . n B 1 155 LEU 155 216 216 LEU LEU B . n B 1 156 ALA 156 217 217 ALA ALA B . n B 1 157 ALA 157 218 218 ALA ALA B . n B 1 158 CYS 158 219 219 CYS CYS B . n B 1 159 THR 159 220 220 THR THR B . n B 1 160 LYS 160 221 221 LYS LYS B . n B 1 161 GLN 161 222 222 GLN GLN B . n B 1 162 TRP 162 223 223 TRP TRP B . n B 1 163 ASP 163 224 224 ASP ASP B . n B 1 164 VAL 164 225 225 VAL VAL B . n B 1 165 VAL 165 226 226 VAL VAL B . n B 1 166 THR 166 227 227 THR THR B . n B 1 167 TYR 167 228 228 TYR TYR B . n B 1 168 LEU 168 229 229 LEU LEU B . n B 1 169 LEU 169 230 230 LEU LEU B . n B 1 170 GLU 170 231 231 GLU GLU B . n B 1 171 ASN 171 232 232 ASN ASN B . n B 1 172 PRO 172 233 233 PRO PRO B . n B 1 173 HIS 173 234 234 HIS HIS B . n B 1 174 GLN 174 235 235 GLN GLN B . n B 1 175 PRO 175 236 236 PRO PRO B . n B 1 176 ALA 176 237 237 ALA ALA B . n B 1 177 SER 177 238 238 SER SER B . n B 1 178 LEU 178 239 239 LEU LEU B . n B 1 179 GLU 179 240 240 GLU GLU B . n B 1 180 ALA 180 241 241 ALA ALA B . n B 1 181 THR 181 242 242 THR THR B . n B 1 182 ASP 182 243 243 ASP ASP B . n B 1 183 SER 183 244 244 SER SER B . n B 1 184 LEU 184 245 245 LEU LEU B . n B 1 185 GLY 185 246 246 GLY GLY B . n B 1 186 ASN 186 247 247 ASN ASN B . n B 1 187 THR 187 248 248 THR THR B . n B 1 188 VAL 188 249 249 VAL VAL B . n B 1 189 LEU 189 250 250 LEU LEU B . n B 1 190 HIS 190 251 251 HIS HIS B . n B 1 191 ALA 191 252 252 ALA ALA B . n B 1 192 LEU 192 253 253 LEU LEU B . n B 1 193 VAL 193 254 254 VAL VAL B . n B 1 194 MET 194 255 255 MET MET B . n B 1 195 ILE 195 256 256 ILE ILE B . n B 1 196 ALA 196 257 257 ALA ALA B . n B 1 197 ASP 197 258 258 ASP ASP B . n B 1 198 ASN 198 259 259 ASN ASN B . n B 1 199 SER 199 260 260 SER SER B . n B 1 200 PRO 200 261 261 PRO PRO B . n B 1 201 GLU 201 262 262 GLU GLU B . n B 1 202 ASN 202 263 263 ASN ASN B . n B 1 203 SER 203 264 264 SER SER B . n B 1 204 ALA 204 265 265 ALA ALA B . n B 1 205 LEU 205 266 266 LEU LEU B . n B 1 206 VAL 206 267 267 VAL VAL B . n B 1 207 ILE 207 268 268 ILE ILE B . n B 1 208 HIS 208 269 269 HIS HIS B . n B 1 209 MET 209 270 270 MET MET B . n B 1 210 TYR 210 271 271 TYR TYR B . n B 1 211 ASP 211 272 272 ASP ASP B . n B 1 212 GLY 212 273 273 GLY GLY B . n B 1 213 LEU 213 274 274 LEU LEU B . n B 1 214 LEU 214 275 275 LEU LEU B . n B 1 215 GLN 215 276 276 GLN GLN B . n B 1 216 MET 216 277 277 MET MET B . n B 1 217 GLY 217 278 278 GLY GLY B . n B 1 218 ALA 218 279 279 ALA ALA B . n B 1 219 ARG 219 280 280 ARG ARG B . n B 1 220 LEU 220 281 281 LEU LEU B . n B 1 221 CYS 221 282 282 CYS CYS B . n B 1 222 PRO 222 283 283 PRO PRO B . n B 1 223 THR 223 284 284 THR THR B . n B 1 224 VAL 224 285 285 VAL VAL B . n B 1 225 GLN 225 286 286 GLN GLN B . n B 1 226 LEU 226 287 287 LEU LEU B . n B 1 227 GLU 227 288 288 GLU GLU B . n B 1 228 GLU 228 289 289 GLU GLU B . n B 1 229 ILE 229 290 290 ILE ILE B . n B 1 230 SER 230 291 291 SER SER B . n B 1 231 ASN 231 292 292 ASN ASN B . n B 1 232 HIS 232 293 293 HIS HIS B . n B 1 233 GLN 233 294 294 GLN GLN B . n B 1 234 GLY 234 295 295 GLY GLY B . n B 1 235 LEU 235 296 296 LEU LEU B . n B 1 236 THR 236 297 297 THR THR B . n B 1 237 PRO 237 298 298 PRO PRO B . n B 1 238 LEU 238 299 299 LEU LEU B . n B 1 239 LYS 239 300 300 LYS LYS B . n B 1 240 LEU 240 301 301 LEU LEU B . n B 1 241 ALA 241 302 302 ALA ALA B . n B 1 242 ALA 242 303 303 ALA ALA B . n B 1 243 LYS 243 304 304 LYS LYS B . n B 1 244 GLU 244 305 305 GLU GLU B . n B 1 245 GLY 245 306 306 GLY GLY B . n B 1 246 LYS 246 307 307 LYS LYS B . n B 1 247 ILE 247 308 308 ILE ILE B . n B 1 248 GLU 248 309 309 GLU GLU B . n B 1 249 ILE 249 310 310 ILE ILE B . n B 1 250 PHE 250 311 311 PHE PHE B . n B 1 251 ARG 251 312 312 ARG ARG B . n B 1 252 HIS 252 313 313 HIS HIS B . n B 1 253 ILE 253 314 314 ILE ILE B . n B 1 254 LEU 254 315 315 LEU LEU B . n B 1 255 GLN 255 316 316 GLN GLN B . n B 1 256 ARG 256 317 317 ARG ARG B . n B 1 257 GLU 257 318 318 GLU GLU B . n B 1 258 PHE 258 319 319 PHE PHE B . n B 1 259 SER 259 320 ? ? ? B . n B 1 260 GLY 260 321 ? ? ? B . n B 1 261 PRO 261 322 ? ? ? B . n B 1 262 TYR 262 323 ? ? ? B . n B 1 263 GLN 263 324 ? ? ? B . n B 1 264 PRO 264 325 ? ? ? B . n B 1 265 LEU 265 326 ? ? ? B . n B 1 266 ALA 266 327 ? ? ? B . n B 1 267 ALA 267 328 ? ? ? B . n B 1 268 ALA 268 329 ? ? ? B . n B 1 269 HIS 269 330 ? ? ? B . n B 1 270 HIS 270 331 ? ? ? B . n B 1 271 HIS 271 332 ? ? ? B . n B 1 272 HIS 272 333 ? ? ? B . n B 1 273 HIS 273 334 ? ? ? B . n B 1 274 HIS 274 335 ? ? ? B . n # loop_ _pdbx_struct_assembly.id _pdbx_struct_assembly.details _pdbx_struct_assembly.method_details _pdbx_struct_assembly.oligomeric_details _pdbx_struct_assembly.oligomeric_count 1 author_defined_assembly ? monomeric 1 2 author_defined_assembly ? monomeric 1 # loop_ _pdbx_struct_assembly_gen.assembly_id _pdbx_struct_assembly_gen.oper_expression _pdbx_struct_assembly_gen.asym_id_list 1 1 A 2 1 B # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2006-06-27 2 'Structure model' 1 1 2008-05-01 3 'Structure model' 1 2 2011-07-13 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Version format compliance' 2 3 'Structure model' 'Version format compliance' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal REFMAC refinement 5.2.0005 ? 1 HKL-2000 'data reduction' . ? 2 SCALEPACK 'data scaling' . ? 3 MOLREP phasing . ? 4 # _pdbx_database_remark.id 999 _pdbx_database_remark.text ;SEQUENCE The SWS database reference Q9WUD2 conflicts with the citation, Caterina et al, 1999, Nature, involving residue 151. Sequence in this entry agrees with the citation. ; # _pdbx_validate_rmsd_bond.id 1 _pdbx_validate_rmsd_bond.PDB_model_num 1 _pdbx_validate_rmsd_bond.auth_atom_id_1 CD _pdbx_validate_rmsd_bond.auth_asym_id_1 A _pdbx_validate_rmsd_bond.auth_comp_id_1 PRO _pdbx_validate_rmsd_bond.auth_seq_id_1 72 _pdbx_validate_rmsd_bond.PDB_ins_code_1 ? _pdbx_validate_rmsd_bond.label_alt_id_1 ? _pdbx_validate_rmsd_bond.auth_atom_id_2 N _pdbx_validate_rmsd_bond.auth_asym_id_2 A _pdbx_validate_rmsd_bond.auth_comp_id_2 PRO _pdbx_validate_rmsd_bond.auth_seq_id_2 72 _pdbx_validate_rmsd_bond.PDB_ins_code_2 ? _pdbx_validate_rmsd_bond.label_alt_id_2 ? _pdbx_validate_rmsd_bond.bond_value 1.622 _pdbx_validate_rmsd_bond.bond_target_value 1.474 _pdbx_validate_rmsd_bond.bond_deviation 0.148 _pdbx_validate_rmsd_bond.bond_standard_deviation 0.014 _pdbx_validate_rmsd_bond.linker_flag N # loop_ _pdbx_validate_rmsd_angle.id _pdbx_validate_rmsd_angle.PDB_model_num _pdbx_validate_rmsd_angle.auth_atom_id_1 _pdbx_validate_rmsd_angle.auth_asym_id_1 _pdbx_validate_rmsd_angle.auth_comp_id_1 _pdbx_validate_rmsd_angle.auth_seq_id_1 _pdbx_validate_rmsd_angle.PDB_ins_code_1 _pdbx_validate_rmsd_angle.label_alt_id_1 _pdbx_validate_rmsd_angle.auth_atom_id_2 _pdbx_validate_rmsd_angle.auth_asym_id_2 _pdbx_validate_rmsd_angle.auth_comp_id_2 _pdbx_validate_rmsd_angle.auth_seq_id_2 _pdbx_validate_rmsd_angle.PDB_ins_code_2 _pdbx_validate_rmsd_angle.label_alt_id_2 _pdbx_validate_rmsd_angle.auth_atom_id_3 _pdbx_validate_rmsd_angle.auth_asym_id_3 _pdbx_validate_rmsd_angle.auth_comp_id_3 _pdbx_validate_rmsd_angle.auth_seq_id_3 _pdbx_validate_rmsd_angle.PDB_ins_code_3 _pdbx_validate_rmsd_angle.label_alt_id_3 _pdbx_validate_rmsd_angle.angle_value _pdbx_validate_rmsd_angle.angle_target_value _pdbx_validate_rmsd_angle.angle_deviation _pdbx_validate_rmsd_angle.angle_standard_deviation _pdbx_validate_rmsd_angle.linker_flag 1 1 CA A PRO 72 ? ? N A PRO 72 ? ? CD A PRO 72 ? ? 102.12 111.50 -9.38 1.40 N 2 1 N A PRO 72 ? ? CA A PRO 72 ? ? CB A PRO 72 ? ? 113.11 102.60 10.51 1.10 N 3 1 CB A GLU 211 ? ? CA A GLU 211 ? ? C A GLU 211 ? ? 86.59 110.40 -23.81 2.00 N 4 1 N A LEU 212 ? ? CA A LEU 212 ? ? CB A LEU 212 ? ? 126.19 110.40 15.79 2.00 N 5 1 N B LYS 201 ? ? CA B LYS 201 ? ? C B LYS 201 ? ? 94.54 111.00 -16.46 2.70 N 6 1 N B LEU 212 ? ? CA B LEU 212 ? ? CB B LEU 212 ? ? 132.49 110.40 22.09 2.00 N # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 GLN A 70 ? ? 41.38 71.00 2 1 GLU A 71 ? ? -156.61 -154.69 3 1 GLN A 203 ? ? -116.82 -77.30 4 1 ASN A 259 ? ? -98.06 36.47 5 1 PHE A 319 ? ? -104.76 69.51 6 1 GLU B 71 ? ? -114.30 -83.58 7 1 SER B 85 ? ? -64.25 -75.50 8 1 PHE B 198 ? ? -66.45 -74.49 9 1 GLN B 200 ? ? 73.90 52.27 10 1 HIS B 234 ? ? -87.31 -72.28 11 1 ASN B 259 ? ? 86.87 6.11 # loop_ _pdbx_validate_peptide_omega.id _pdbx_validate_peptide_omega.PDB_model_num _pdbx_validate_peptide_omega.auth_comp_id_1 _pdbx_validate_peptide_omega.auth_asym_id_1 _pdbx_validate_peptide_omega.auth_seq_id_1 _pdbx_validate_peptide_omega.PDB_ins_code_1 _pdbx_validate_peptide_omega.label_alt_id_1 _pdbx_validate_peptide_omega.auth_comp_id_2 _pdbx_validate_peptide_omega.auth_asym_id_2 _pdbx_validate_peptide_omega.auth_seq_id_2 _pdbx_validate_peptide_omega.PDB_ins_code_2 _pdbx_validate_peptide_omega.label_alt_id_2 _pdbx_validate_peptide_omega.omega 1 1 GLN B 200 ? ? LYS B 201 ? ? 146.17 2 1 GLU B 211 ? ? LEU B 212 ? ? -147.42 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 B PHE 198 ? CG ? B PHE 137 CG 2 1 Y 1 B PHE 198 ? CD1 ? B PHE 137 CD1 3 1 Y 1 B PHE 198 ? CD2 ? B PHE 137 CD2 4 1 Y 1 B PHE 198 ? CE1 ? B PHE 137 CE1 5 1 Y 1 B PHE 198 ? CE2 ? B PHE 137 CE2 6 1 Y 1 B PHE 198 ? CZ ? B PHE 137 CZ 7 1 Y 1 B PHE 199 ? CG ? B PHE 138 CG 8 1 Y 1 B PHE 199 ? CD1 ? B PHE 138 CD1 9 1 Y 1 B PHE 199 ? CD2 ? B PHE 138 CD2 10 1 Y 1 B PHE 199 ? CE1 ? B PHE 138 CE1 11 1 Y 1 B PHE 199 ? CE2 ? B PHE 138 CE2 12 1 Y 1 B PHE 199 ? CZ ? B PHE 138 CZ 13 1 Y 1 B GLN 200 ? CG ? B GLN 139 CG 14 1 Y 1 B GLN 200 ? CD ? B GLN 139 CD 15 1 Y 1 B GLN 200 ? OE1 ? B GLN 139 OE1 16 1 Y 1 B GLN 200 ? NE2 ? B GLN 139 NE2 17 1 Y 1 B LYS 201 ? CG ? B LYS 140 CG 18 1 Y 1 B LYS 201 ? CD ? B LYS 140 CD 19 1 Y 1 B LYS 201 ? CE ? B LYS 140 CE 20 1 Y 1 B LYS 201 ? NZ ? B LYS 140 NZ # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A LYS 62 ? A LYS 1 2 1 Y 1 A ASN 63 ? A ASN 2 3 1 Y 1 A THR 64 ? A THR 3 4 1 Y 1 A SER 65 ? A SER 4 5 1 Y 1 A ALA 66 ? A ALA 5 6 1 Y 1 A PRO 67 ? A PRO 6 7 1 Y 1 A SER 68 ? A SER 7 8 1 Y 1 A GLY 321 ? A GLY 260 9 1 Y 1 A PRO 322 ? A PRO 261 10 1 Y 1 A TYR 323 ? A TYR 262 11 1 Y 1 A GLN 324 ? A GLN 263 12 1 Y 1 A PRO 325 ? A PRO 264 13 1 Y 1 A LEU 326 ? A LEU 265 14 1 Y 1 A ALA 327 ? A ALA 266 15 1 Y 1 A ALA 328 ? A ALA 267 16 1 Y 1 A ALA 329 ? A ALA 268 17 1 Y 1 A HIS 330 ? A HIS 269 18 1 Y 1 A HIS 331 ? A HIS 270 19 1 Y 1 A HIS 332 ? A HIS 271 20 1 Y 1 A HIS 333 ? A HIS 272 21 1 Y 1 A HIS 334 ? A HIS 273 22 1 Y 1 A HIS 335 ? A HIS 274 23 1 Y 1 B LYS 62 ? B LYS 1 24 1 Y 1 B ASN 63 ? B ASN 2 25 1 Y 1 B THR 64 ? B THR 3 26 1 Y 1 B SER 65 ? B SER 4 27 1 Y 1 B ALA 66 ? B ALA 5 28 1 Y 1 B PRO 67 ? B PRO 6 29 1 Y 1 B SER 68 ? B SER 7 30 1 Y 1 B GLN 69 ? B GLN 8 31 1 Y 1 B HIS 202 ? B HIS 141 32 1 Y 1 B GLN 203 ? B GLN 142 33 1 Y 1 B SER 320 ? B SER 259 34 1 Y 1 B GLY 321 ? B GLY 260 35 1 Y 1 B PRO 322 ? B PRO 261 36 1 Y 1 B TYR 323 ? B TYR 262 37 1 Y 1 B GLN 324 ? B GLN 263 38 1 Y 1 B PRO 325 ? B PRO 264 39 1 Y 1 B LEU 326 ? B LEU 265 40 1 Y 1 B ALA 327 ? B ALA 266 41 1 Y 1 B ALA 328 ? B ALA 267 42 1 Y 1 B ALA 329 ? B ALA 268 43 1 Y 1 B HIS 330 ? B HIS 269 44 1 Y 1 B HIS 331 ? B HIS 270 45 1 Y 1 B HIS 332 ? B HIS 271 46 1 Y 1 B HIS 333 ? B HIS 272 47 1 Y 1 B HIS 334 ? B HIS 273 48 1 Y 1 B HIS 335 ? B HIS 274 #